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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pde6anmf363
neuroscience mutagenesis facility, 363
MGI:3828520
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pde6anmf363/Pde6anmf363 C57BL/6J-Pde6anmf363/J MGI:3828991
hm2
 		Pde6anmf363/Pde6anmf363 involves: A/J * C57BL/6J MGI:3828994
ht3
 		Pde6anmf282/Pde6anmf363 involves: A/J * C57BL/6J MGI:3828995
cx4
 		Pde6anmf363/Pde6a+
Pde6brd1-2J/Pde6b+ 		C57BL/6J-Pde6brd1-2J Pde6anmf363 MGI:3828997


Genotype
MGI:3828991
hm1
Allelic
Composition		 Pde6anmf363/Pde6anmf363
Genetic
Background		 C57BL/6J-Pde6anmf363/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6anmf363 mutation (0 available); any Pde6a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina photoreceptor degeneration ( J:142108 )
• degradation of the outer segment is observed at P19
• however, dark-rearing mice on a pure C57BL/6J background slows the progression of photoreceptor degeneration
thin retina outer nuclear layer ( J:142108 )
• at P14, the outer nuclear layer is reduced in thickness by 30% compared to in wild-type mice
• Background Sensitivity: at P19, dark-reared mice on a C57BL/6J background exhibit reduced outer nuclear layer thickness compared to in wild-type mice that is not as severe as in homozygotes raised in standard lighting conditions
• at P30, a single layer of cell bodies remains in the outer nuclear layer
• however, dark-reared mice on a pure C57BL/6J background exhibit normal retinal outer nuclear layer thickness at P14
abnormal eye electrophysiology ( J:142108 )
• some residual activity is measured at P21
• Background Sensitivity: when mice are on a pure C57BL/6J background, a and b waves in dark-reared homozygotes are larger than mice reared under standard light conditions but smaller than in wild-type mice

nervous system
retina photoreceptor degeneration ( J:142108 )
• degradation of the outer segment is observed at P19
• however, dark-rearing mice on a pure C57BL/6J background slows the progression of photoreceptor degeneration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa DOID:10584 OMIM:PS268000
 J:142108




Genotype
MGI:3828994
hm2
Allelic
Composition		 Pde6anmf363/Pde6anmf363
Genetic
Background		 involves: A/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6anmf363 mutation (0 available); any Pde6a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina photoreceptor cell number ( J:142108 )
• Background Sensitivity: photoreceptor loss in dark-reared or mice raised under standard light conditions are equivalent when mice are on a mixed A/J C57BL/6J background
short photoreceptor outer segment ( J:142108 )
• reduced outer segment thickness in dark-reared or mice raised under standard light conditions are equivalent when mice are on a mixed A/J C57BL/6J background
thin retina outer nuclear layer ( J:142108 )
• Background Sensitivity: reduced outer nuclear layer in dark-reared or mice raised under standard light conditions are equivalent when mice are on a mixed A/J C57BL/6J background

nervous system
decreased retina photoreceptor cell number ( J:142108 )
• Background Sensitivity: photoreceptor loss in dark-reared or mice raised under standard light conditions are equivalent when mice are on a mixed A/J C57BL/6J background
short photoreceptor outer segment ( J:142108 )
• reduced outer segment thickness in dark-reared or mice raised under standard light conditions are equivalent when mice are on a mixed A/J C57BL/6J background




Genotype
MGI:3828995
ht3
Allelic
Composition		 Pde6anmf282/Pde6anmf363
Genetic
Background		 involves: A/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6anmf282 mutation (1 available); any Pde6a mutation (52 available)
Pde6anmf363 mutation (0 available); any Pde6a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor outer segment ( J:142108 )
• reduced thickness is intermediate to that observed in homozygote of either parental alleles
thin retina outer nuclear layer ( J:142108 )
• reduced thickness is intermediate to that observed in homozygote of either parental alleles

nervous system
short photoreceptor outer segment ( J:142108 )
• reduced thickness is intermediate to that observed in homozygote of either parental alleles




Genotype
MGI:3828997
cx4
Allelic
Composition		 Pde6anmf363/Pde6a+
Pde6brd1-2J/Pde6b+
Genetic
Background		 C57BL/6J-Pde6brd1-2J Pde6anmf363
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6anmf363 mutation (0 available); any Pde6a mutation (52 available)
Pde6brd1-2J mutation (1 available); any Pde6b mutation (122 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:142108 )
N
• a and b wave response is normal at 5 to 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory