Phenotypes associated with this allele

• Allele Symbol: Pcdha^tm4Tyag
• Allele Name: targeted mutation 4, Takeshi Yagi
• Allele ID: MGI:3829037
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcdha^tm4Tyag/Pcdha^tm4Tyag	involves: C57BL/6 * CBA	MGI:3829205

Genotype
MGI:3829205

hm1

• Allelic Composition: Pcdha^tm4Tyag/Pcdha^tm4Tyag
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:143248 )

N • mice exhibit normal learning in a Morris water maze

abnormal contextual conditioning behavior ( J:143248 )

• 24 hours after training, mice exhibit increased freezing in a contextual fear-conditioning test compared to wild-type mice

• however, cued-conditioning is normal

abnormal spatial working memory ( J:143248 )

• mice exhibit decreased working memory errors in an eight-arm radial maze compared to wild-type mice

• however, distance traveled is normal

homeostasis/metabolism

abnormal serotonin level ( J:143248 )

• 5-HT levels in the hippocampus are increased compared to in wild-type mice

nervous system

nervous system phenotype ( J:143248 )

N • despite behavioral abnormalities, brain morphology is normal