Phenotypes associated with this allele

• Allele Symbol: Prss21^tm1Tba
• Allele Name: targeted mutation 1, Tadashi Baba
• Allele ID: MGI:3829187
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss21^tm1Tba/Prss21^tm1Tba	involves: 129S2/SvPas * ICR	MGI:3829188

Genotype
MGI:3829188

hm1

• Allelic Composition: Prss21^tm1Tba/Prss21^tm1Tba
• Genetic Background: involves: 129S2/SvPas * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired fertilization ( J:142458 )

• the in vitro fertilization rate of epididymal sperm from homozygous mutant mice was increased by pretreatment of the sperm with uterine fluid

impaired acrosome reaction ( J:142458 )

♂ • epididymal sperm from homozygous mutant mice failed to undergo the acrosome reaction on the zona pellucida surface in in vitro fertilization with cumulus-intact eggs

♂ • however, spontaneous acrosome reaction occurred normally in in vitro fertilization medium

♂ • wild-type female mice artificially inseminated by injection of capacitated epididymal sperm from homozygous mutant mice fertilize eggs normally

♂ • both male and female mice showed normal fertility and normal litter size

impaired sperm penetration of zona pellucida ( J:142458 )

♂ • the penetration rate of epididymal sperm from homozygous mutant mice passing through the Cd9^tm1Mek homozygous egg zona pellucida was significantly low in in vitro fertilization

impaired binding of sperm to zona pellucida ( J:142458 )

♂ • binding of epididymal sperm from homozygous mutant mice to egg zona pellucida was reduced in in vitro fertilization with cumulus-intact eggs