Phenotypes associated with this allele

• Allele Symbol: Nedd4^Gt(XB398)Byg
• Allele Name: gene trap XB398, BayGenomics
• Allele ID: MGI:3829273
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nedd4^Gt(XB398)Byg/Nedd4^Gt(XB398)Byg	involves: 129P2/OlaHsd	MGI:3829356

Genotype
MGI:3829356

hm1

• Allelic Composition: Nedd4^Gt(XB398)Byg/Nedd4^Gt(XB398)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased T cell proliferation ( J:143560 )

• following antigen stimulation in fetal liver chimeras, T cell proliferation is less than in similarly treated wild-type chimeras

• however, treatment with IL-2 results in normal proliferation rates

mortality/aging

perinatal lethality, complete penetrance ( J:143560 )

• mice die at birth

preweaning lethality, complete penetrance ( J:207675 )

• no mice are present at weaning

hematopoietic system

decreased T cell proliferation ( J:143560 )

• following antigen stimulation in fetal liver chimeras, T cell proliferation is less than in similarly treated wild-type chimeras

• however, treatment with IL-2 results in normal proliferation rates

decreased B cell number ( J:143560 )

• in fetal liver chimeras, the percentage of B cell and CD11b+ cells in the lymph nodes and spleens is slightly lower than in wild-type chimeras

increased T cell number ( J:143560 )

• in fetal liver chimeras, the number of T cells in the spleen is larger than in wild-type chimeras

increased CD4-positive, alpha-beta T cell number ( J:143560 )

• in fetal liver chimeras, the percentage of CD4+ and CD8+ cells in the lymph nodes and spleens is increased compared to in wild-type chimeras

increased CD8-positive, alpha-beta T cell number ( J:143560 )

• in fetal liver chimeras, the percentage of CD4+ and CD8+ cells in the lymph nodes and spleens is increased compared to in wild-type chimeras

decreased IgG1 level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

decreased IgG2b level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

decreased IgG3 level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

increased IgM level ( J:143560 )

• in fetal liver chimeras following immunization

immune system

decreased T cell proliferation ( J:143560 )

• following antigen stimulation in fetal liver chimeras, T cell proliferation is less than in similarly treated wild-type chimeras

• however, treatment with IL-2 results in normal proliferation rates

decreased B cell number ( J:143560 )

• in fetal liver chimeras, the percentage of B cell and CD11b+ cells in the lymph nodes and spleens is slightly lower than in wild-type chimeras

increased T cell number ( J:143560 )

• in fetal liver chimeras, the number of T cells in the spleen is larger than in wild-type chimeras

increased CD4-positive, alpha-beta T cell number ( J:143560 )

• in fetal liver chimeras, the percentage of CD4+ and CD8+ cells in the lymph nodes and spleens is increased compared to in wild-type chimeras

increased CD8-positive, alpha-beta T cell number ( J:143560 )

• in fetal liver chimeras, the percentage of CD4+ and CD8+ cells in the lymph nodes and spleens is increased compared to in wild-type chimeras

decreased IgG1 level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

decreased IgG2b level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

decreased IgG3 level ( J:143560 )

• fetal liver chimeras exhibit decreased IgG1, IgG2 (a and b) and IgG3 both pre- and post-immunization compared to wild-type chimeras

increased IgM level ( J:143560 )

• in fetal liver chimeras following immunization

decreased interleukin-2 secretion ( J:143560 )

• in T cells from fetal liver chimeras that were cultured with anti-CD3 and anti-CD28