All Phenotypes Pvr<tm1Hfuk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pvr^tm1Hfuk
targeted mutation 1, H Fukui
MGI:3829366

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pvr^tm1Hfuk/Pvr^tm1Hfuk	involves: 129X1/SvJ * C57BL/6 * DBA	MGI:3829372
ht2	Pvr^tm1Hfuk/Pvr⁺	involves: 129X1/SvJ * C57BL/6 * DBA	MGI:3829373

Allelic Composition	Pvr^tm1Hfuk/Pvr^tm1Hfuk
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvr^tm1Hfuk mutation (0 available); any Pvr mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:143250 )

• mice treated with DSS or DSS and DMH exhibit reduced mucosal ulcerations compared to similarly treated wild-type mice

• mice treated with DSS or DSS and DMH exhibit reduced inflammatory infiltration in the colonic mucosa compared to similarly treated wild-type mice

• mice treated with DSS or DSS and DMH exhibit a reduced increased in cellular proliferation in the colonic mucosa compared to in similarly treated wild-type mice that is more severe than in Pvr^tm1Hfuk heterozygotes

decreased incidence of tumors by chemical induction ( J:143250 )

• mice treated with DMH (dimethylhydrazine) and DSS (dextran sulphate sodium) exhibit reduced occurrence and severity of colon tumors compared to similarly treated wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:143250 )

• mice treated with DMH (dimethylhydrazine) and DSS (dextran sulphate sodium) exhibit reduced occurrence and severity of colon tumors compared to similarly treated wild-type mice

Allelic Composition	Pvr^tm1Hfuk/Pvr⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvr^tm1Hfuk mutation (0 available); any Pvr mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:143250 )

• mice treated with DSS or DSS and DMH exhibit reduced mucosal ulcerations compared to similarly treated wild-type mice

• mice treated with DSS or DSS and DMH exhibit reduced inflammatory infiltration in the colonic mucosa compared to similarly treated wild-type mice

• mice treated with DSS or DSS and DMH exhibit a reduced increased in cellular proliferation in the colonic mucosa compared to in similarly treated wild-type mice that is not as severe as in Pvr^tm1Hfuk homozygotes

decreased incidence of tumors by chemical induction ( J:143250 )

• mice treated with DMH (dimethylhydrazine) and DSS (dextran sulphate sodium) exhibit reduced occurrence and severity of colon tumors compared to similarly treated wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:143250 )

• mice treated with DMH (dimethylhydrazine) and DSS (dextran sulphate sodium) exhibit reduced occurrence and severity of colon tumors compared to similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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