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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rorc-EGFP)1Ebe
transgene insertion 1, Gerard Eberl
MGI:3829387
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3829420
cx2
 		Il12rb1tm1Jm/Il12rb1tm1Jm
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S1/Sv * C57BL/6 MGI:3829419
cx3
 		Il6tm1Kopf/Il6tm1Kopf
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S2/SvPas * C57BL/6 MGI:3829418
cx4
 		Foxp3sf/Foxp3sf
Tg(Rorc-EGFP)1Ebe/? 		involves: C57BL/6 MGI:3829421
cx5
 		ApcMin/Apc+
Tg(Rorc-EGFP)1Ebe/? 		involves: C57BL/6 MGI:3829423


Genotype
MGI:3829420
cx1
Allelic
Composition		 Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation (3 available); any Ccr6 mutation (37 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased

hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased




Genotype
MGI:3829419
cx2
Allelic
Composition		 Il12rb1tm1Jm/Il12rb1tm1Jm
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb1tm1Jm mutation (2 available); any Il12rb1 mutation (33 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased

immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased




Genotype
MGI:3829418
cx3
Allelic
Composition		 Il6tm1Kopf/Il6tm1Kopf
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
• numbers of Th17 gammadelta T cells are normal

immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
• numbers of Th17 gammadelta T cells are normal




Genotype
MGI:3829421
cx4
Allelic
Composition		 Foxp3sf/Foxp3sf
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3sf mutation (5 available); any Foxp3 mutation (58 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts

immune system
abnormal effector T cell morphology ( J:137020 )
• mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts




Genotype
MGI:3829423
cx5
Allelic
Composition		 ApcMin/Apc+
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell morphology ( J:137020 )
• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls
• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring
enlarged mesenteric lymph nodes ( J:137020 )
• mesenteric lymph nodes are hyperplastic
lymph node hyperplasia ( J:137020 )
• mesenteric lymph nodes are hyperplastic

digestive/alimentary system
intestine polyps ( J:137020 )
• ileal polyps occur in these mice
colon polyps ( J:137020 )
• occur in these mice

hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls
• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory