Phenotypes associated with this allele

• Allele Symbol: Lrig3^tm1.1Good
• Allele Name: targeted mutation 1.1, Lisa Goodrich
• Allele ID: MGI:3829388
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrig3^tm1.1Good/Lrig3^tm1.1Good	B6N.Cg-Lrig3^tm1.1Good	MGI:5551810
hm2	Lrig3^tm1.1Good/Lrig3^tm1.1Good	involves: BALB/cJ	MGI:3829401
cx3	Lrig1^Gt(GST4169C6)Lex/Lrig1^Gt(GST4169C6)Lex Lrig3^tm1.1Good/Lrig3^tm1.1Good	B6N.Cg-Lrig1^Gt(GST4169C6)Lex Lrig3^tm1.1Good	MGI:5551793
cx4	Lrig1^Gt(GST4169C6)Lex/Lrig1^+ Lrig3^tm1.1Good/Lrig3^tm1.1Good	B6N.Cg-Lrig1^Gt(GST4169C6)Lex Lrig3^tm1.1Good	MGI:5551795

Genotype
MGI:5551810

hm1

• Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good
• Genetic Background: B6N.Cg-Lrig3^tm1.1Good

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:202451 )

• truncation or thinning is seen in 4 of 12 mice

decreased posterior semicircular canal size ( J:202451 )

Genotype
MGI:3829401

hm2

• Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good
• Genetic Background: involves: BALB/cJ

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:142510 )

• mice exhibit the same defects as observed in Lrig3^{Gt(LST016)Byg}

craniofacial

abnormal craniofacial morphology ( J:142510 )

• mice exhibit the same defects as observed in Lrig3^{Gt(LST016)Byg}

Genotype
MGI:5551793

cx3

• Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex}; Lrig3^tm1.1Good/Lrig3^tm1.1Good
• Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good

mortality/aging

perinatal lethality, complete penetrance ( J:202451 )

• die at or before birth

hearing/vestibular/ear

abnormal inner ear development ( J:202451 )

• more severely disrupted than in either single mutant

abnormal lateral semicircular canal morphology ( J:202451 )

• small and misshapen in 5 of 10 mice

abnormal posterior semicircular canal morphology ( J:202451 )

• seen in 6 of 10 mice

decreased posterior semicircular canal size ( J:202451 )

abnormal otolith organ morphology ( J:202451 )

• saccule and utricle fail to separate in 10 of 10 mice

vision/eye

microphthalmia ( J:202451 )

skeleton

abnormal skeleton morphology ( J:202451 )

• skeletal malformations

Genotype
MGI:5551795

cx4

• Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺; Lrig3^tm1.1Good/Lrig3^tm1.1Good
• Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:202451 )

• seen in 2 of 10 mice

• similar to Lrig3 single mutant mice