Phenotypes associated with this allele

• Allele Symbol: Igh-7^tm1Gach
• Allele Name: targeted mutation 1, Gernot Achatz
• Allele ID: MGI:3829432
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-7^tm1Gach/Igh-7^tm1Gach	BALB/c-Igh-7^tm1Gach	MGI:3829451

Genotype
MGI:3829451

hm1

• Allelic Composition: Igh-7^tm1Gach/Igh-7^tm1Gach
• Genetic Background: BALB/c-Igh-7^tm1Gach

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

enhanced B cell migration ( J:143266 )

• enhanced migration of IgE antibody secreting cells in culture along a gradient of CXCL12 concentration which, in the mouse, would guide these cells to the bone marrow

immune system

enhanced B cell migration ( J:143266 )

• enhanced migration of IgE antibody secreting cells in culture along a gradient of CXCL12 concentration which, in the mouse, would guide these cells to the bone marrow

abnormal B cell number ( J:143266 )

increased memory B cell number ( J:143266 )

• increased numbers of IgE antibody secreting cells in immunized mice at 28 days when they are undetectable in controls

increased plasma cell number ( J:143266 )

• numbers of IgE antibody secreting cells in both bone marrow and spleen are roughly proportional to serum levels of IgE

increased IgE level ( J:143266 )

• moderately elevated in serum at 8 weeks relative to controls (1.6ug/ml vs 1ug/ml)

• considerably elevated in serum at 8 months relative to controls (6.6ug/ml vs 1.7ug/ml)

• IgE titers increase more rapidly after booster injections with T-cell dependent antigen, especially after a second booster

hematopoietic system

enhanced B cell migration ( J:143266 )

• enhanced migration of IgE antibody secreting cells in culture along a gradient of CXCL12 concentration which, in the mouse, would guide these cells to the bone marrow

abnormal B cell number ( J:143266 )

increased memory B cell number ( J:143266 )

• increased numbers of IgE antibody secreting cells in immunized mice at 28 days when they are undetectable in controls

increased plasma cell number ( J:143266 )

• numbers of IgE antibody secreting cells in both bone marrow and spleen are roughly proportional to serum levels of IgE

increased IgE level ( J:143266 )

• moderately elevated in serum at 8 weeks relative to controls (1.6ug/ml vs 1ug/ml)

• considerably elevated in serum at 8 months relative to controls (6.6ug/ml vs 1.7ug/ml)

• IgE titers increase more rapidly after booster injections with T-cell dependent antigen, especially after a second booster