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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrbtm5Slek
targeted mutation 5, Barry P Sleckman
MGI:3829440
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrbtm5Slek/Tcrbtm5Slek Not Specified MGI:3829443
ht2
 		Tcrbtm1Slek/Tcrbtm5Slek Not Specified MGI:3829444


Genotype
MGI:3829443
hm1
Allelic
Composition		 Tcrbtm5Slek/Tcrbtm5Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm5Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• recombination of the Tcrb locus is inefficient
• 22% of alphabeta T cells have one allele of Tcrb that has failed to recombine compared to none in T cells from controls
• there is also decreased transcription of the germline sequence

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• recombination of the Tcrb locus is inefficient
• 22% of alphabeta T cells have one allele of Tcrb that has failed to recombine compared to none in T cells from controls
• there is also decreased transcription of the germline sequence




Genotype
MGI:3829444
ht2
Allelic
Composition		 Tcrbtm1Slek/Tcrbtm5Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
Tcrbtm5Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory