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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrbtm6Slek
targeted mutation 6, Barry P Sleckman
MGI:3829441
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrbtm6Slek/Tcrbtm6Slek Not Specified MGI:3829445
ht2
 		Tcrbtm1Slek/Tcrbtm6Slek Not Specified MGI:3829447


Genotype
MGI:3829445
hm1
Allelic
Composition		 Tcrbtm6Slek/Tcrbtm6Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm6Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement fails to occur at the Tcrb locus

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement fails to occur at the Tcrb locus




Genotype
MGI:3829447
ht2
Allelic
Composition		 Tcrbtm1Slek/Tcrbtm6Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
Tcrbtm6Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory