All Phenotypes Tg(Ttr-cre)1Hadj MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Ttr-cre)1Hadj
transgene insertion 1, Anna-Katerina Hadjantonakis
MGI:3829595

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rac1^tm1Tyb/Rac1^tm2Tyb Tg(Ttr-cre)1Hadj/0	involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J	MGI:5050120
cn2	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J	MGI:5523430
cn3	Arl8b^tm1Kkon/Arl8b^tm1Kkon Tg(Ttr-cre)1Hadj/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6107945
cn4	Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Tg(Ttr-cre)1Hadj/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6841002

Allelic Composition	Rac1^tm1Tyb/Rac1^tm2Tyb Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac1^tm1Tyb mutation (0 available); any Rac1 mutation (24 available)
Rac1^tm2Tyb mutation (0 available); any Rac1 mutation (24 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:166095 )

• survive longer than germ line null mice, up to E8.25

embryo

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression

abnormal rostral-caudal axis patterning ( J:166095 )

• expression analysis indicates a defect in the initial specification of the AP axis in most embryos

embryonic-extraembryonic boundary constriction ( J:166095 )

• constriction at the boundary between embryonic and extraembryonic regions

abnormal extraembryonic endoderm formation ( J:173526 )

• visceral endoderm cells fail to form a border around the midline structures

craniofacial

abnormal craniofacial development ( J:166095 )

• abnormal headfolds at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:198636 )

N	• heterozygous females present at the expected ratio at weaning

Allelic Composition	Arl8b^tm1Kkon/Arl8b^tm1Kkon Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl8b^tm1Kkon mutation (0 available); any Arl8b mutation (24 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:245627 )

• at E8.5

abnormal embryonic tissue physiology ( J:245627 )

• decreased amino acid levels in the embryo

abnormal visceral yolk sac morphology ( J:245627 )

• the visceral yolk sac is relatively opaque at E8.5

abnormal visceral yolk sac endoderm morphology ( J:245627 )

• hypertrophic visceral yolk sac endoderm with accumulation of vesicles at E8.5

abnormal extraembryonic tissue physiology ( J:245627 )

• accumulation of maternal albumin and IgG and impaired maturation of cathepsin L in the visceral yolk sac

• reduced levels of almost all amino acids and metabolites produced by the central metabolic pathways in the visceral yolk sac

homeostasis/metabolism

abnormal amino acid level ( J:245627 )

• decreased amino acid levels in the embryo

growth/size/body

decreased embryo size ( J:245627 )

• at E8.5

Allelic Composition	Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef7^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Arhgef7 mutation (54 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

abnormal primitive streak morphology ( J:217373 )

• double axis at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

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