About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sohlh2tm1Miya
targeted mutation 1, Jun-ichi Miyazaki
MGI:3829597
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sohlh2tm1Miya/Sohlh2tm1Miya involves: 129P2/OlaHsd * C57BL/6 MGI:3829605


Genotype
MGI:3829605
hm1
Allelic
Composition		 Sohlh2tm1Miya/Sohlh2tm1Miya
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh2tm1Miya mutation (1 available); any Sohlh2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatocyte morphology ( J:143535 )
• during adult spermatogenesis, almost no spermatocytes are observed unlike in wild-type mice
abnormal spermatogonia morphology ( J:143535 )
• while undifferentiated spermatogonia appear normal, differentiated cells degenerate
absent ovarian follicles ( J:143535 )
• mice lack follicles and their development cannot be initiated by treatment with gonadotrophin
impaired ovarian folliculogenesis ( J:143535 )
• at P3, oocytes and follicles are smaller and asymmetrical compared to in wild-type mice
• at P7, most follicles degenerate and surrounding cells remain flat unlike in wild-type mice
• follicular development is defective in the primordial-to-primary follicle formation
female infertility ( J:143535 )
• despite normal sexual behavior, mice are sterile
male infertility ( J:143535 )
• despite normal sexual behavior, mice are sterile

endocrine/exocrine glands
absent ovarian follicles ( J:143535 )
• mice lack follicles and their development cannot be initiated by treatment with gonadotrophin
impaired ovarian folliculogenesis ( J:143535 )
• at P3, oocytes and follicles are smaller and asymmetrical compared to in wild-type mice
• at P7, most follicles degenerate and surrounding cells remain flat unlike in wild-type mice
• follicular development is defective in the primordial-to-primary follicle formation

cellular
abnormal spermatocyte morphology ( J:143535 )
• during adult spermatogenesis, almost no spermatocytes are observed unlike in wild-type mice
abnormal spermatogonia morphology ( J:143535 )
• while undifferentiated spermatogonia appear normal, differentiated cells degenerate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory