mortality/aging
• die around E11.5 - E13.5
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cardiovascular system
• the lumens of the right and left cardinal veins are morbidly enlarged
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• at E10.5 to E12.5
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• at E10.5, alignment of parallel thick and thin filaments is disorganized and the distribution of thick and thin filaments is unbalanced
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• the lumen is morbidly enlarged
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• variable degrees of pericardial effusion are seen
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• some embryos show severe hemorrhage in the cardiac and ventral body wall regions
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muscle
• at E10.5 to E12.5
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homeostasis/metabolism
• variable degrees of pericardial effusion are seen
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