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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17ftm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:3830035
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il17ftm1Yiw/Il17ftm1Yiw involves: 129P2/OlaHsd * C57BL/6 MGI:3830058
cx2
 		Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw 		involves: 129 * BALB/c MGI:3830054
cx3
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw 		involves: 129 * BALB/c MGI:3830055
cx4
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw 		involves: 129P2/OlaHsd * C57BL/6 MGI:3830059


Genotype
MGI:3830058
hm1
Allelic
Composition		 Il17ftm1Yiw/Il17ftm1Yiw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ftm1Yiw mutation (0 available); any Il17f mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:143719 )
• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium than in controls
• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium
• C. rodentium infection leads to more severe histopathology of the colon, and significantly increases crypt length




Genotype
MGI:3830054
cx2
Allelic
Composition		 Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ftm1Yiw mutation (0 available); any Il17f mutation (28 available)
Il1rntm1Yiw mutation (0 available); any Il1rn mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:143719 )
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele

skeleton
rheumatoid arthritis ( J:143719 )
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele




Genotype
MGI:3830055
cx3
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il17ftm1Yiw mutation (0 available); any Il17f mutation (28 available)
Il1rntm1Yiw mutation (0 available); any Il1rn mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:143719 )
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes

skeleton
rheumatoid arthritis ( J:143719 )
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes




Genotype
MGI:3830059
cx4
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il17ftm1Yiw mutation (0 available); any Il17f mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:143719 )
• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium
• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium
• C. rodentium infection leads to more severe histopathology of the colon than controls, and significantly increases crypt length




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory