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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17ftm2Yiw
targeted mutation 2, Yoichiro Iwakura
MGI:3830038
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm2Yiw/Il17ftm2Yiw 		B6.129P2-Il17atm1Yiw Il17ftm2Yiw MGI:3830057
cx2
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm2Yiw/Il17ftm2Yiw 		involves: 129P2/OlaHsd * BALB/c MGI:3830056


Genotype
MGI:3830057
cx1
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm2Yiw/Il17ftm2Yiw
Genetic
Background		 B6.129P2-Il17atm1Yiw Il17ftm2Yiw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il17ftm2Yiw mutation (0 available); any Il17f mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to infection induced morbidity/mortality ( J:160680 )
• decreased survival rate in response to i.v C. albicans NBRC1385 infection

immune system
increased IgG1 level ( J:143719 )
• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2a level ( J:143719 )
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2b level ( J:143719 )
• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
decreased IgG3 level ( J:143719 )
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
enlarged submandibular lymph nodes ( J:143719 )
• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age
• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment
increased susceptibility to infection induced morbidity/mortality ( J:160680 )
• decreased survival rate in response to i.v C. albicans NBRC1385 infection

hematopoietic system
increased IgG1 level ( J:143719 )
• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2a level ( J:143719 )
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2b level ( J:143719 )
• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
decreased IgG3 level ( J:143719 )
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls




Genotype
MGI:3830056
cx2
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm2Yiw/Il17ftm2Yiw
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (25 available)
Il17ftm2Yiw mutation (0 available); any Il17f mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgG1 level ( J:143719 )
• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2a level ( J:143719 )
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2b level ( J:143719 )
• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
decreased IgG3 level ( J:143719 )
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
enlarged submandibular lymph nodes ( J:143719 )
• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age
• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment
nasal inflammation ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
increased susceptibility to bacterial infection ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
• S. aureus is readily culturable from mucosal surfaces of the nose and mouth but is not culturable from controls
• mice have the same resistance to systemic infection of S. aureus as determined by survival curves and the amount of colony forming units in kidney homegenates after inoculation with S. aureus

craniofacial
mouth mucosal ulcer ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

digestive/alimentary system
mouth mucosal ulcer ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

respiratory system
nasal inflammation ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

hematopoietic system
increased IgG1 level ( J:143719 )
• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2a level ( J:143719 )
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
increased IgG2b level ( J:143719 )
• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
decreased IgG3 level ( J:143719 )
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls

growth/size/body
mouth mucosal ulcer ( J:143719 )
• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory