Phenotypes associated with this allele

• Allele Symbol: Erap1^tm1.1Gnie
• Allele Name: targeted mutation 1.1, Gabriele Niedermann
• Allele ID: MGI:3830089
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erap1^tm1.1Gnie/Erap1^tm1.1Gnie	involves: 129S6/SvEvTac * C57BL/6	MGI:3830222

Genotype
MGI:3830222

hm1

• Allelic Composition: Erap1^tm1.1Gnie/Erap1^tm1.1Gnie
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:143988 )

• when mice are injected successively with MHC class I-mismatched splenocytes and CFSE-labeled naive CD8+ T cells expressing a specific TCR, proliferation of cross-primed CD8+ T cells is reduced by two-thirds compared to similarly treated wild-type cells

abnormal cytotoxic T cell physiology ( J:143988 )

• cytotoxic response to immunodominant NP396-404 is decreased compared to in wild-type cells

• however, cytotoxic response to LCMV (lymphocytic choriomeningitis virus) infection is normal

abnormal antigen presentation ( J:143988 )

• mice exhibit reduced efficiency of cross-presentation of cell-associated antigens and of ovalbumin/anti-ovalbumin immunocomplexes

• however, cross-presentation of soluble ovalbumin is normal

decreased level of surface class I molecules ( J:143988 )

• expression of MHC class I proteins at the cell surface is reduced in splenocytes, dendritic cells from bone marrow precursors, and immature bone marrow-derived dendritic cells treated with IFN-gamma compared to similarly treated wild-type cells

• however, expression of MHC class II proteins at the cell surface is normal

decreased interferon-gamma secretion ( J:143988 )

• NP396-404 specific cytotoxic T lymphocytes stimulated by LCMV-infected dendritic cells derived from bone marrow precursors produce less IFN-gamma than similarly treated wild-type cells

• however, prepulsed dendritic cells stimulate cytotoxic T lymphocytes normally

abnormal response to infection ( J:143988 )

• mice primed with the NP396-404 peptide and challenged with LCMV exhibit reduced clearance efficiency compared to similarly treated wild-type mice

• however, response to LCMV (lymphocytic choriomeningitis virus) infection is otherwise normal

hematopoietic system

decreased T cell proliferation ( J:143988 )

• when mice are injected successively with MHC class I-mismatched splenocytes and CFSE-labeled naive CD8+ T cells expressing a specific TCR, proliferation of cross-primed CD8+ T cells is reduced by two-thirds compared to similarly treated wild-type cells

abnormal cytotoxic T cell physiology ( J:143988 )

• cytotoxic response to immunodominant NP396-404 is decreased compared to in wild-type cells

• however, cytotoxic response to LCMV (lymphocytic choriomeningitis virus) infection is normal

cellular

decreased T cell proliferation ( J:143988 )

• when mice are injected successively with MHC class I-mismatched splenocytes and CFSE-labeled naive CD8+ T cells expressing a specific TCR, proliferation of cross-primed CD8+ T cells is reduced by two-thirds compared to similarly treated wild-type cells