Phenotypes associated with this allele

• Allele Symbol: Cthrc1^tm1Haak
• Allele Name: targeted mutation 1, Haruhiko Akiyama
• Allele ID: MGI:3830252
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cthrc1^tm1Haak/Cthrc1^tm1Haak	B6.129S-Cthrc1^tm1Haak	MGI:3830292

Genotype
MGI:3830292

hm1

• Allelic Composition: Cthrc1^tm1Haak/Cthrc1^tm1Haak
• Genetic Background: B6.129S-Cthrc1^tm1Haak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:143940 )

• at 2 months, bone formation rates are less than in wild-type mice

decreased osteoblast proliferation ( J:143940 )

• in vitro, osteoblasts from newborn mice exhibit a 40% reduction in proliferation compared to wild-type cells

• at 2 months, the number of proliferating osteoblasts is 30% less than in wild-type mice

skeleton

skeleton phenotype ( J:143940 )

N • despite abnormal osteoblast morphology and physiology, osteoclast morphology and physiology are normal

abnormal osteoblast physiology ( J:143940 )

• at 2 months, bone formation rates are less than in wild-type mice

decreased osteoblast proliferation ( J:143940 )

• in vitro, osteoblasts from newborn mice exhibit a 40% reduction in proliferation compared to wild-type cells

• at 2 months, the number of proliferating osteoblasts is 30% less than in wild-type mice

abnormal osteoblast morphology ( J:143940 )

• at 2 months, the osteoblast surface is 40% less than in wild-type mice

decreased osteoblast cell number ( J:143940 )

• at 2 months

decreased bone trabecula number ( J:143940 )

• in adult mice, the number of trabeculae is reduced compared to in wild-type mice

• however, trabecular thickness is normal

decreased trabecular bone mass ( J:143940 )

• at 2 months, the trabecular bone mass is reduced 70% compared to in wild-type mice

abnormal bone ossification ( J:143940 )

• cultured bone marrow cells have reduced osteoprogenitors, and half as much mineralization area is produced by colony forming unit-osteoblasts compared to wild-type bone marrow