All Phenotypes Tg(Col1a1-Cthrc1)1Haak MGI Mouse

skeleton phenotype ( J:143940 )

N	• despite abnormal osteoblast morphology and physiology, osteoclast morphology and physiology are normal

abnormal osteoblast physiology ( J:143940 )

• osteoblast surface is increased 50% compared to in wild-type mice

• bone formation rate is increased compared to in wild-type mice

• ovariectomized mice exhibit increased bone formation compared to similarly treated wild-type mice

increased osteoblast proliferation ( J:143940 )

• in vitro, osteoblasts from newborn mice exhibit a 25% increase in proliferation compared to wild-type cells

• osteoblast proliferation is increased 35% compared to in wild-type mice

increased osteoblast cell number ( J:143940 )

abnormal trabecular bone morphology ( J:143940 )

• despite ovariectomy, trabecular numbers and thickness are increased compared to in similarly treated wild-type mice

• however, trabecular thickness is normal in mice with intact ovaries

increased bone trabecula number ( J:143940 )

• trabecular number is increased compared to in wild-type mice

increased bone mass ( J:143940 )

• bone mass loss in ovariectomized mice is 17% less than in similarly treated wild-type mice

increased trabecular bone mass ( J:143940 )

• tibia trabecular bone mass is increased 25% compared to in wild-type mice

abnormal bone ossification ( J:143940 )

• cultured bone marrow cells have more osteoprogenitors and mineralization area produced by colony forming unit-osteoblasts compared to wild-type bone marrow