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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nodaltm2Mku
targeted mutation 2, Michael R Kuehn
MGI:3830289
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nodaltm1.1Mku/Nodaltm2Mku involves: 129S1/Sv MGI:3830290
cn2
 		Nodaltm1.1Mku/Nodaltm2Mku
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * C3H * C57BL/6 MGI:3830291


Genotype
MGI:3830290
ht1
Allelic
Composition		 Nodaltm1.1Mku/Nodaltm2Mku
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.1Mku mutation (0 available); any Nodal mutation (42 available)
Nodaltm2Mku mutation (1 available); any Nodal mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:142430 )
• viable with no signs of left right patterning defects




Genotype
MGI:3830291
cn2
Allelic
Composition		 Nodaltm1.1Mku/Nodaltm2Mku
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.1Mku mutation (0 available); any Nodal mutation (42 available)
Nodaltm2Mku mutation (1 available); any Nodal mutation (42 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal direction of heart looping ( J:142430 )
• the direction of looping is reversed in about half of the embryos at E8.5 - E9.5

embryo
embryo phenotype ( J:142430 )
N
• unlike in mice heterozygous for Nodal tm1Mku and Nodal tm1.1Mku, no midline or anterior/head morphological defects are detected
abnormal left-right axis patterning ( J:142430 )
• expression analysis indicates complete loss of asymmetric signals in the lateral plate mesoderm

growth/size/body
right pulmonary isomerism ( J:142430 )
• by E13.5

hematopoietic system
small spleen ( J:142430 )
• small or absent
absent spleen ( J:142430 )
• small or absent

immune system
small spleen ( J:142430 )
• small or absent
absent spleen ( J:142430 )
• small or absent

respiratory system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory