All Phenotypes Adcy6<tm1Hkh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adcy6^tm1Hkh
targeted mutation 1, H Kirk Hammond
MGI:3830298

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy6^tm1Hkh/Adcy6^tm1Hkh	involves: 129S1/Sv * 129X1/SvJ	MGI:3830301

Allelic Composition	Adcy6^tm1Hkh/Adcy6^tm1Hkh
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy6^tm1Hkh mutation (0 available); any Adcy6 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

• reduced dobutamin affect on left ventricular fractional shortening

• reduced left ventricular ejection fraction

• left ventricular pressure development is reduced in isolated perfused hearts

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:143138 )

• calcium ion uptake by the sarcoplasmic reticulum is reduced at a variety of calcium concentrations

• caffein stimulated calcium transients in cardiac myocytes are reduced around 50%

muscle

• reduced dobutamin affect on left ventricular fractional shortening

• reduced left ventricular ejection fraction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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