Phenotypes associated with this allele

• Allele Symbol: Il20rb^tm1Uwe
• Allele Name: targeted mutation 1, Ursula Maria Wegenka
• Allele ID: MGI:3830304
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il20rb^tm1Uwe/Il20rb^tm1Uwe	B6.129P2-Il20rb^tm1Uwe	MGI:3830309
hm2	Il20rb^tm1Uwe/Il20rb^tm1Uwe	C.129P2-Il20rb^tm1Uwe	MGI:3830310

Genotype
MGI:3830309

hm1

• Allelic Composition: Il20rb^tm1Uwe/Il20rb^tm1Uwe
• Genetic Background: B6.129P2-Il20rb^tm1Uwe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:143497 )

• CD4 and CD8 T cells stimulated in vitro have higher rates of proliferation than in controls

increased memory T cell number ( J:143497 )

• 2- to 3- fold higher antigen-specific CD8 T cells are generated compared to controls after secondary boost with a hepatitis-S antigen DNA vaccine

abnormal T-helper 1 physiology ( J:143497 )

• higher numbers of antigen specific CD4 Th1 T cells are generated to two different types of DNA vaccines (one to hepatitis-S antigen, and one to OVA antigen)

abnormal cytotoxic T cell physiology ( J:143497 )

• higher numbers of antigen specific CD8 T cells are generated to two different types of DNA vaccines (one to hepatitis-S antigen, and one to OVA antigen)

increased interferon-gamma secretion ( J:143497 )

• CD4 and CD8 T cells stimulated in vitro have higher rates of IFN-gamma secretion than controls with levels of secretion almost twice those as controls with 72 hours of stimulation

decreased interleukin-10 secretion ( J:143497 )

• CD4 T cells stimulated in vitro have lower rates of IL-10 secretion than controls with levels of secretion almost half those as controls with 1 to 3 days of stimulation

increased interleukin-2 secretion ( J:143497 )

• CD4 and CD8 T cells stimulated in vitro have higher rates of IL-2 secretion than controls with levels of secretion almost twice those as controls with 48 hours of stimulation

decreased interleukin-4 secretion ( J:143497 )

• CD4 T cells stimulated in vitro have lower rates of IL-4 secretion than controls with levels of secretion almost half those as controls with 1 to 2 days of stimulation

hematopoietic system

increased T cell proliferation ( J:143497 )

• CD4 and CD8 T cells stimulated in vitro have higher rates of proliferation than in controls

increased memory T cell number ( J:143497 )

• 2- to 3- fold higher antigen-specific CD8 T cells are generated compared to controls after secondary boost with a hepatitis-S antigen DNA vaccine

abnormal T-helper 1 physiology ( J:143497 )

• higher numbers of antigen specific CD4 Th1 T cells are generated to two different types of DNA vaccines (one to hepatitis-S antigen, and one to OVA antigen)

abnormal cytotoxic T cell physiology ( J:143497 )

• higher numbers of antigen specific CD8 T cells are generated to two different types of DNA vaccines (one to hepatitis-S antigen, and one to OVA antigen)

cellular

increased T cell proliferation ( J:143497 )

• CD4 and CD8 T cells stimulated in vitro have higher rates of proliferation than in controls

Genotype
MGI:3830310

hm2

• Allelic Composition: Il20rb^tm1Uwe/Il20rb^tm1Uwe
• Genetic Background: C.129P2-Il20rb^tm1Uwe

immune system

increased susceptibility to type IV hypersensitivity reaction ( J:143497 )

• mice have significantly more ear swelling in response to the contact allergen TNCB