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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp1tm3Ajmr
targeted mutation 3, Anton J M Roebroek
MGI:3830332
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp1tm3Ajmr/Lrp1tm3Ajmr involves: 129P2/OlaHsd * C57BL/6 MGI:3830350


Genotype
MGI:3830350
hm1
Allelic
Composition		 Lrp1tm3Ajmr/Lrp1tm3Ajmr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm3Ajmr mutation (1 available); any Lrp1 mutation (211 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:144146 )
• all mice die at or shortly after birth
lethality throughout fetal growth and development, incomplete penetrance ( J:144146 )
• fewer than expected mice are found at E14.5

liver/biliary system
decreased hepatocyte number ( J:144146 )
• hepatocytes are lost between E16.5 and E18.5
abnormal liver perisinusoidal space morphology ( J:144146 )
• from E16.5 to birth, the space of Disse is enlarged with scattered larger gaps presumably caused by loss of hematopoietic stem cells
liver degeneration ( J:144146 )
• after E15, liver tissue is progressively destroyed unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory