Phenotypes associated with this allele

• Allele Symbol: Rap1a^tm1Tze
• Allele Name: targeted mutation 1, Tomasz Zemojtel
• Allele ID: MGI:3830343
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rap1a^tm1Tze/Rap1a^tm1Tze	involves: 129P2/OlaHsd * C57BL/6	MGI:3830358

Genotype
MGI:3830358

hm1

• Allelic Composition: Rap1a^tm1Tze/Rap1a^tm1Tze
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte adhesion ( J:144145 )

• splenocytes and thymocytes have lower adhesion to fibronectin coated plates

• only half as many splenocytes adhere after 30 minutes compared to controls

• adherence to ICAM was also less than controls, with larger differences observed upon activation

• both T and B cells demonstrate decreased ability to bind to ICAM compared to controls

decreased T cell proliferation ( J:144145 )

• T cells stimulated by anti-CD3 treatment have much less proliferation than wild-type controls

• there is also less proliferation than controls in response to anti-CD3/CD28 stimulation

decreased interleukin-2 secretion ( J:144145 )

• activated T cells secrete less IL-2 than wild-type controls with the biggest difference occurring with anti-CD3 stimulation

hematopoietic system

abnormal leukocyte adhesion ( J:144145 )

• splenocytes and thymocytes have lower adhesion to fibronectin coated plates

• only half as many splenocytes adhere after 30 minutes compared to controls

• adherence to ICAM was also less than controls, with larger differences observed upon activation

• both T and B cells demonstrate decreased ability to bind to ICAM compared to controls

decreased T cell proliferation ( J:144145 )

• T cells stimulated by anti-CD3 treatment have much less proliferation than wild-type controls

• there is also less proliferation than controls in response to anti-CD3/CD28 stimulation

cellular

abnormal leukocyte adhesion ( J:144145 )

• splenocytes and thymocytes have lower adhesion to fibronectin coated plates

• only half as many splenocytes adhere after 30 minutes compared to controls

• adherence to ICAM was also less than controls, with larger differences observed upon activation

• both T and B cells demonstrate decreased ability to bind to ICAM compared to controls

decreased T cell proliferation ( J:144145 )

• T cells stimulated by anti-CD3 treatment have much less proliferation than wild-type controls

• there is also less proliferation than controls in response to anti-CD3/CD28 stimulation