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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Inpp5dtm1Wgk
targeted mutation 1, William G Kerr
MGI:3830362
Summary 2 genotypes


Genotype
MGI:3830385
cn1
Allelic
Composition		 Inpp5dtm1Wgk/Inpp5dtm1.1Wgk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1.1Wgk mutation (1 available); any Inpp5d mutation (94 available)
Inpp5dtm1Wgk mutation (1 available); any Inpp5d mutation (94 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal myeloid leukocyte morphology ( J:144110 )
• Cd11b+Gr+ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction
• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction
• when cre expression is only partially induced, significant increase in MySC numbers are still observed
abnormal leukocyte physiology ( J:144110 )
• Cd11b +Gr+ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction
• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity

hematopoietic system
abnormal myeloid leukocyte morphology ( J:144110 )
• Cd11b+Gr+ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction
• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction
• when cre expression is only partially induced, significant increase in MySC numbers are still observed
abnormal leukocyte physiology ( J:144110 )
• Cd11b +Gr+ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction
• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity




Genotype
MGI:3830386
cn2
Allelic
Composition		 Inpp5dtm1Wgk/Inpp5dtm1Wgk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1Wgk mutation (1 available); any Inpp5d mutation (94 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to graft versus host disease ( J:144110 )
• in mice in which cre expression is induced, there is a 94% survival rate in irradiated mutant mice receiving wild-type BALB/c bone marrow compared to controls that only had a 57% survival rate
• these mice also have higher weights and have fewer manifestations of GVHD including better skin texture, less fur loss, and more activity
• donor bone marrow engraftment occurred in the mutant mice suggesting the allogenic immune cells present in the mice were being suppressed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory