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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smarca4tm1Tich
targeted mutation 1, Tian Chi
MGI:3830390
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Smarca4tm1Tich/Smarca4+ involves: 129 MGI:3830515
cn2
 		Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0 		involves: 129 MGI:3830511
cn3
 		Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0 		involves: 129 MGI:3830512
cn4
 		Smarca4tm1Tich/Smarca4+
Tg(Lck-cre)1Cwi/0 		involves: 129 MGI:3830516


Genotype
MGI:3830515
ht1
Allelic
Composition		 Smarca4tm1Tich/Smarca4+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:144072 )
N
• despite reduced levels of CD8 expression, mice exhibit normal numbers of cells in the DN4 compartment




Genotype
MGI:3830511
cn2
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (110 available)
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• 38% of the post-DN3 population is composed of CD4+CD8- cells compared to 14% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is not observed
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• post-DN3 T cells are reduced compared to in wild-type mice
• however, DN3 cellularity is normal

hematopoietic system
abnormal T cell morphology ( J:144072 )
• 38% of the post-DN3 population is composed of CD4+CD8- cells compared to 14% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is not observed
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• post-DN3 T cells are reduced compared to in wild-type mice
• however, DN3 cellularity is normal

endocrine/exocrine glands
decreased thymocyte number ( J:144072 )
• thymocyte numbers are reduced 13-fold compared to in wild-type mice




Genotype
MGI:3830512
cn3
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1Tich
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (110 available)
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed
• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• mice exhibit two CD4+ populations with different levels of CD4 expression

hematopoietic system
abnormal T cell morphology ( J:144072 )
• unlike in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population is not observed
• 25% of the post-DN3 population is composed of CD4-DN4 cells compared to 9% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 39% of the post-DN3 population is composed of CD4+DN4 cells compared to 52% in Smarca4tm1Grc/Smarca4tm1Grc Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• mice exhibit two CD4+ populations with different levels of CD4 expression

endocrine/exocrine glands




Genotype
MGI:3830516
cn4
Allelic
Composition		 Smarca4tm1Tich/Smarca4+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1Tich mutation (0 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• DN4 cells are completely missing
decreased single-positive T cell number ( J:144072 )
• immature single positive cells are lost

hematopoietic system
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice
decreased double-negative T cell number ( J:144072 )
• DN4 cells are completely missing
decreased single-positive T cell number ( J:144072 )
• immature single positive cells are lost

endocrine/exocrine glands
decreased thymocyte number ( J:144072 )
• total thymocyte numbers are slightly reduced compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory