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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bhlhe22tm2(cre)Gan
targeted mutation 2, Lin Gan
MGI:3830517
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bhlhe22tm1Gan/Bhlhe22tm2(cre)Gan
Tg(CAG-Bgeo/GFP)21Lbe/0 		involves: 129S/Sv * 129X1/SvJ * C57BL/6J MGI:3830525


Genotype
MGI:3830525
cn1
Allelic
Composition		 Bhlhe22tm1Gan/Bhlhe22tm2(cre)Gan
Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic
Background		 involves: 129S/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Gan mutation (0 available); any Bhlhe22 mutation (12 available)
Bhlhe22tm2(cre)Gan mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal corticospinal tract morphology ( J:144066 )
• at P0, no Bhlhe22-expression fibers are detected in the medullary pyramidal tract unlike in wild-type mice
• in adults, few Bhlhe22-expression fibers are detected in the medullary pyramidal tract unlike in wild-type mice
• Bhlhe22-expression fibers present in the decussation do not enter the ventral dorsal funiculus of the spinal cord unlike in wild-type mice
• fewer than normal subcerebral projection neurons enter the medullary pyramidal tract while caudal corticospinal motor neurons fail to enter the tract




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory