Phenotypes associated with this allele

• Allele Symbol: Kcnq3^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3830636
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq3^tm1Dgen/Kcnq3^tm1Dgen	Not Specified	MGI:3830650

Genotype
MGI:3830650

hm1

• Allelic Composition: Kcnq3^tm1Dgen/Kcnq3^tm1Dgen
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:142688 )

• hippocampal slices fail to generate an outward current when treated with retigabine unlike wild-type tissue

• however, the apamin-insensitive medium afterhyperpolarization current is normally blocked by XE991 in hippocampal pyramidal cells

nervous system

abnormal afterhyperpolarization ( J:142688 )

• however, the apamin-insensitive medium and slow afterhyperpolarization currents in hippocampal pyramidal cells are normal

• granule cells exhibit decreased apamin-insensitive medium afterhyperpolarization current

• apamin-insensitive slow afterhyperpolarization current of dentate granule cells is reduced 50% compared to in wild-type cells