Phenotypes associated with this allele

• Allele Symbol: Rimbp3^tm1Gxu
• Allele Name: targeted mutation 1, Guo-Liang Xu
• Allele ID: MGI:3830663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rimbp3^tm1Gxu/Rimbp3^tm1Gxu	involves: 129/Sv * ICR	MGI:3830664

Genotype
MGI:3830664

hm1

• Allelic Composition: Rimbp3^tm1Gxu/Rimbp3^tm1Gxu
• Genetic Background: involves: 129/Sv * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:144218 )

N • weights of seminal vesicle, testes, and cauda epididymis are similar to controls

N • the histology of spermatogonia, spermatocytes, and Sertoli cells is similar to controls

detached sperm flagellum ( J:144218 )

♂ • seen in a high number of sperm

kinked sperm flagellum ( J:144218 )

♂ • some flagella show various degrees of bending

oligozoospermia ( J:144218 )

♂ • caudal epididymal sperm counts are reduced by 1/3 compared to controls

abnormal sperm head morphology ( J:144218 )

♂ • expanded perinuclear space

detached acrosome ( J:144218 )

♂ • present in about 90% or sperm

abnormal sperm nucleus morphology ( J:144218 )

♂ • abnormal sperm heads exhibit a deformed nucleus

♂ • step 12 spermatids display deformed nuclei

abnormal spermatid morphology ( J:144218 )

♂ • abnormalities can be seen as early as step 5

♂ • step 12 spermatids display deformed nuclei

♂ • elongating and elongated spermatids appear structurally to be most severely affected

ectopic manchette ( J:144218 )

♂ • the manchette has a symmetrical conical shape, is ectopically located, and is oriented parallel to the longitudinal axis

abnormal spermiogenesis ( J:144218 )

♂ • proacrosomal vesicles fail to fuse to form a single large acrosomal vesicle and the acroplaxome is bent at several sites

♂ • the manchette has a symmetrical conical shape, is ectopically located, and is oriented parallel to the longitudinal axis

male infertility ( J:144218 )

♂ • males are sexually active and produce vaginal plugs but over a 2 month mating period only 1 female became pregnant and gave birth to a single pup

impaired fertilization ( J:144218 )

• following crosses to superovulated females only 9.3% of eggs were fertilized compared to 92.4% for wild-type controls

cellular

detached sperm flagellum ( J:144218 )

♂ • seen in a high number of sperm

kinked sperm flagellum ( J:144218 )

♂ • some flagella show various degrees of bending

oligozoospermia ( J:144218 )

♂ • caudal epididymal sperm counts are reduced by 1/3 compared to controls

abnormal sperm head morphology ( J:144218 )

♂ • expanded perinuclear space

detached acrosome ( J:144218 )

♂ • present in about 90% or sperm

abnormal sperm nucleus morphology ( J:144218 )

♂ • abnormal sperm heads exhibit a deformed nucleus

♂ • step 12 spermatids display deformed nuclei

abnormal spermatid morphology ( J:144218 )

♂ • abnormalities can be seen as early as step 5

♂ • step 12 spermatids display deformed nuclei

♂ • elongating and elongated spermatids appear structurally to be most severely affected

ectopic manchette ( J:144218 )

♂ • the manchette has a symmetrical conical shape, is ectopically located, and is oriented parallel to the longitudinal axis