Phenotypes associated with this allele

• Allele Symbol: Id2^tm1Mcha
• Allele Name: targeted mutation 1, Matthew C Havrda
• Allele ID: MGI:3830733
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id2^tm1Mcha/Id2^tm1Mcha	involves: C57BL/6 * CD-1	MGI:3830737

Genotype
MGI:3830737

hm1

• Allelic Composition: Id2^tm1Mcha/Id2^tm1Mcha
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:143882 )

N • despite loss of dopaminergic neurons in the olfactory periglomular cell layer, mice do not exhibit an increase in apoptosis in the rostral migratory stream

premature neuronal precursor differentiation ( J:143882 )

• in culture, neurospheres exhibit a greater percent of cells expressing GFAP compared to wild-type cells indicating premature astroglial differentiation

abnormal neuronal precursor proliferation ( J:143882 )

• in culture, neurospheres are small and exhibit slower growth and decreased S-phase populations compared to wild-type cells

abnormal olfactory bulb morphology ( J:143882 )

• the internal plexiform layer (IPL) was reduced in size and disorganized compared to in wild-type mice

• the IPL exhibits loss of dendrodendritic fibers compared to in wild-type mice likely due to a loss of granular interneurons

• however, olfactory bulbs exhibit normal numbers of mitral, tufted and oligodendroglia cells, and CR+ GABAergic neurons

• the number of NeuN+ interneurons is decreased in the granular cell layer and IPL compared to in wild-type mice

• the number of GFAP+ astroglial cells in the granular cell layer is increased compared to in wild-type mice

• TH+ dopaminergic neurons are depleted 40% in the periglomerular cell layer of the olfactory bulb compared to in wild-type mice

• the number of GFAP+ cells with astrocytic morphology in the inner granular and germinal layers of the olfactory bulb emanating from the rostral migratory stream is increased compared to in wild-type mice

abnormal rostral migratory stream morphology ( J:143882 )

• the rostral migratory stream is decrease in diameter and GFAP/BrdU ectopic cells are found outside of the stream unlike in wild-type mice

• unlike in wild-type mice, elongated cells are absent from the rostral migratory stream

• however, the number of neural progenitor cells is normal

small olfactory bulb ( J:143882 )

• olfactory bulb size is diminished without alteration to brain size

loss of dopaminergic neurons ( J:143882 )

• TH+ dopaminergic neurons are depleted 40% in the periglomerular cell layer of the olfactory bulb compared to in wild-type mice

taste/olfaction

abnormal olfaction ( J:143882 )

• mice exhibit defects in olfactory memory and discrimination compared to wild-type mice

• however, olfactory sensitivity is normal

cellular

premature neuronal precursor differentiation ( J:143882 )

• in culture, neurospheres exhibit a greater percent of cells expressing GFAP compared to wild-type cells indicating premature astroglial differentiation

abnormal neuronal precursor proliferation ( J:143882 )

• in culture, neurospheres are small and exhibit slower growth and decreased S-phase populations compared to wild-type cells