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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2tm1Irt
targeted mutation 1, Ira Tabas
MGI:3830735
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3830961
cn2
 		Apoetm1Bres/Apoetm1Bres
Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3830965


Genotype
MGI:3830961
cn1
Allelic
Composition		 Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Irt mutation (1 available); any Bcl2 mutation (41 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased macrophage apoptosis ( J:144243 )
• peritoneal macrophages show increased susceptibility to apoptosis induced by free cholesterol loading and to oxidized LDL; increased susceptibility to UV irradiation and the phosphatase inhibitor staurosporine is also observed relative to controls

cellular
increased macrophage apoptosis ( J:144243 )
• peritoneal macrophages show increased susceptibility to apoptosis induced by free cholesterol loading and to oxidized LDL; increased susceptibility to UV irradiation and the phosphatase inhibitor staurosporine is also observed relative to controls

hematopoietic system
increased macrophage apoptosis ( J:144243 )
• peritoneal macrophages show increased susceptibility to apoptosis induced by free cholesterol loading and to oxidized LDL; increased susceptibility to UV irradiation and the phosphatase inhibitor staurosporine is also observed relative to controls




Genotype
MGI:3830965
cn2
Allelic
Composition		 Apoetm1Bres/Apoetm1Bres
Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Bres mutation (9 available); any Apoe mutation (158 available)
Bcl2tm1Irt mutation (1 available); any Bcl2 mutation (41 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased macrophage apoptosis ( J:144243 )
• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks

cardiovascular system
cardiovascular system phenotype ( J:144243 )
N
• after 4 weeks on a Western diet, mice have similar lesion areas in proximal aortas and no or very rarely detected macrophage apoptosis in the lesions, very similar to pathology observed in controls
atherosclerotic lesions ( J:144243 )
• 8 week-old mice fed a Western diet for 4 weeks display proximal aorta lesions similar to control animals
• necrotic areas observed in lesions are larger than observed in controls after receiving a Western diet for 10 weeks

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:144243 )
N
• mice show similar weights and levels of plasma lipoproteins to controls after 4 weeks on a Western diet

cellular
increased macrophage apoptosis ( J:144243 )
• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks

hematopoietic system
increased macrophage apoptosis ( J:144243 )
• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory