Phenotypes associated with this allele

• Allele Symbol: Tgfbi^tm1Zhao
• Allele Name: targeted mutation 1, Yongliang Zhao
• Allele ID: MGI:3830817
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfbi^tm1Zhao/Tgfbi^tm1Zhao	involves: 129 * C57BL/6J	MGI:3830822

Genotype
MGI:3830822

hm1

• Allelic Composition: Tgfbi^tm1Zhao/Tgfbi^tm1Zhao
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:143036 )

• between 9 and 16 months, more than 20% of mice die due to systematic illness unlike wild-type mice

neoplasm

increased tumor incidence ( J:143036 )

• after 20 months, 37% of mice develop tumors compared to 13% of heterozygotes and 8% of wild-type mice

increased incidence of tumors by chemical induction ( J:143036 )

• 10 of 23 mice treated with DMBA develop skin tumors compared to 2 of 21 similarly treated wild-type mice

increased lymphoma incidence ( J:143036 )

• in three mice

increased malignant tumor incidence ( J:143036 )

• 4 of 12 mice develop malignancies

increased lung adenocarcinoma incidence ( J:143036 )

• in one mouse

cellular

abnormal cell nucleus morphology ( J:143036 )

• the frequency of micronuclei in early passage mouse embryonic fibroblasts is increased 4.7-fold compared to in wild-type cells

abnormal chromosome morphology ( J:143036 )

• 44% of mouse embryonic fibroblasts treated with colcemid exhibit chromosomal aberrations (including chromosomal breaks, centric fragments or chromatid breaks) compared to 13% of similarly treated wild-type cells

growth/size/body

decreased body weight ( J:143036 )

• at 2 to 6 months of age, mice weigh 13.5% less than wild-type mice

postnatal growth retardation ( J:143036 )

enlarged spleen ( J:143036 )

• in two mice due to B cell hyperplasia

immune system

enlarged spleen ( J:143036 )

• in two mice due to B cell hyperplasia

increased B cell number ( J:143036 )

• two mice exhibit splenomegaly due to B cell hyperplasia

hematopoietic system

enlarged spleen ( J:143036 )

• in two mice due to B cell hyperplasia

increased B cell number ( J:143036 )

• two mice exhibit splenomegaly due to B cell hyperplasia

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:143036 )

• 10 of 23 mice treated with DMBA develop skin tumors compared to 2 of 21 similarly treated wild-type mice

respiratory system

increased lung adenocarcinoma incidence ( J:143036 )

• in one mouse