All Phenotypes Bub1<tm1.1Tvd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bub1^tm1.1Tvd/Bub1^tm1.1Tvd	B6.129P2-Bub1^tm1.1Tvd	MGI:3830993
hm2	Bub1^tm1.1Tvd/Bub1^tm1.1Tvd	FVB.129P2-Bub1^tm1.1Tvd	MGI:3830992
hm3	Bub1^tm1.1Tvd/Bub1^tm1.1Tvd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:3830991
ht4	Bub1^tm1.1Tvd/Bub1⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:3830990
ht5	Bub1^Gt(XG453)Byg/Bub1^tm1.1Tvd	involves: 129P2/OlaHsd * C57BL/6J	MGI:3830995

Allelic Composition	Bub1^tm1.1Tvd/Bub1^tm1.1Tvd
Genetic Background	B6.129P2-Bub1^tm1.1Tvd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Tvd mutation (0 available); any Bub1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:143035 )

• Background Sensitivity: nearly all mice die perinatally unlike on a congenic FVB background in which survival is normal or on a mixed C57BL/6 background in which survival is reduced

• however, 2 mice survive to weaning

growth/size/body

decreased birth weight ( J:143035 )

• at birth, mice weigh less than wild-type mice and exhibit a failure to thrive

hematopoietic system

anemia ( J:143035 )

• mild at E18.5

increased leukocyte cell number ( J:143035 )

• mild at E18.5

liver/biliary system

hepatic necrosis ( J:143035 )

• liver cell death is observed at E18.5

pale liver ( J:143035 )

• at E18.5

immune system

increased leukocyte cell number ( J:143035 )

• mild at E18.5

Allelic Composition	Bub1^tm1.1Tvd/Bub1^tm1.1Tvd
Genetic Background	FVB.129P2-Bub1^tm1.1Tvd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Tvd mutation (0 available); any Bub1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:143035 )

N	• Background Sensitivity: mice are born at Mendelian ratios unlike on a mixed or congenic C57BL/6 background

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:143035 )

• only 20% of expected mice from the fourth generation on this background are alive at birth unlike on a congenic FVB background in which mice survive normally or on a congenic C57BL/6 background in which nearly all mice die perinatally

cellular

aneuploidy ( J:143035 )

• 76% of mouse embryonic fibroblasts exhibit aneuploidy compared to 9% of wild-type cells

abnormal cell cycle ( J:143035 )

• mouse embryonic fibroblast cells exhibit increases in spindle assembly and chromosome congression defects compared to wild-type cells

abnormal cell cycle checkpoint function ( J:143035 )

• nocodazole-treated mouse embryonic fibroblasts exhibit only a modestly lower increase in mitotic index compared to similarly treated wild-type cells

abnormal mitotic spindle assembly checkpoint ( J:143035 )

• taxol-treated mouse embryonic fibroblasts exhibit severe defects in spindle assembly checkpoints compared to in similarly treated wild-type cells

abnormal mitotic spindle morphology ( J:143035 )

• mouse embryonic fibroblast cells exhibit increases in spindle assembly defects

decreased fibroblast proliferation ( J:143035 )

• mouse embryonic fibroblasts exhibit impaired growth compared to wild-type cells

early cellular replicative senescence ( J:143035 )

• mouse embryonic fibroblasts exhibit higher rates of senescence compared to wild-type cells

neoplasm

increased liver tumor incidence ( J:143035 )

• the majority of tumors are of liver origins

increased incidence of induced tumors ( J:143035 )

• 76% of mice develop tumors by 23 to 25 months of age compared to 28% of wild-type mice

increased lung tumor incidence ( J:143035 )

• 16% of mice develop lung tumors compared to no wild-type mice

liver/biliary system

increased liver tumor incidence ( J:143035 )

• the majority of tumors are of liver origins

respiratory system

increased lung tumor incidence ( J:143035 )

• 16% of mice develop lung tumors compared to no wild-type mice

Allelic Composition	Bub1^tm1.1Tvd/Bub1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Tvd mutation (0 available); any Bub1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

aneuploidy ( J:143035 )

• 23% of mouse embryonic fibroblasts exhibit aneuploidy compared to 9% of wild-type cells

neoplasm

increased brain tumor incidence ( J:143035 )

• mice exhibit brain tumors unlike wild-type mice

increased lung tumor incidence ( J:143035 )

• mice exhibit lung tumors unlike wild-type mice

nervous system

increased brain tumor incidence ( J:143035 )

• mice exhibit brain tumors unlike wild-type mice

respiratory system

increased lung tumor incidence ( J:143035 )

• mice exhibit lung tumors unlike wild-type mice

Allelic Composition	Bub1^Gt(XG453)Byg/Bub1^tm1.1Tvd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^Gt(XG453)Byg mutation (0 available); any Bub1 mutation (52 available)
Bub1^tm1.1Tvd mutation (0 available); any Bub1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:143035 )

• when Bub1^Gt(XG453)Byg is inherited paternally, no mice are present at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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