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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfbr1tm1Bopa
targeted mutation 1, Boris Pasche
MGI:3831090
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tgfbr1tm1Bopa/Tgfbr1tm1Bopa B6.129S1-Tgfbr1tm1Bopa MGI:3831110
cx2
 		ApcMin/Apc+
Tgfbr1tm1Bopa/Tgfbr1+ 		B6.Cg-Tgfbr1tm1Bopa ApcMin MGI:3831112
cx3
 		Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+ 		involves: 129S1/SvImJ * C57BL/6 * FVB MGI:5806470
cx4
 		Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Tg(Mt1-TGFBR2*)AM3Epb/0 		involves: 129S1/SvImJ * C57BL/6 * FVB MGI:5806471
cx5
 		ApcMin/Apc+
Tgfbr1tm1Bopa/Tgfbr1+ 		involves: 129S1/SvImJ * C57BL/6J MGI:3831111


Genotype
MGI:3831110
hm1
Allelic
Composition		 Tgfbr1tm1Bopa/Tgfbr1tm1Bopa
Genetic
Background		 B6.129S1-Tgfbr1tm1Bopa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:143706 )
• dead embryos are found in a ratio of 1 to 4 at the time of collection of mouse embryonic fibroblasts
• no mice survive to be born




Genotype
MGI:3831112
cx2
Allelic
Composition		 ApcMin/Apc+
Tgfbr1tm1Bopa/Tgfbr1+
Genetic
Background		 B6.Cg-Tgfbr1tm1Bopa ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:143706 )
• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
increased intestinal adenocarcinoma incidence ( J:143706 )
• 3 mice develop large, polyploidy and ulcerated colonic tumors

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:143706 )
• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
increased intestinal adenocarcinoma incidence ( J:143706 )
• 3 mice develop large, polyploidy and ulcerated colonic tumors




Genotype
MGI:5806470
cx3
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreas tumor incidence ( J:231759 )
• only 40% of mice present with neoplastic or metaplastic pancreatic lesions
abnormal pancreas physiology ( J:231759 )
• decrease in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:231759 )
• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

immune system
increased CD8-positive, alpha-beta T cell number ( J:231759 )
• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

neoplasm
increased pancreas tumor incidence ( J:231759 )
• only 40% of mice present with neoplastic or metaplastic pancreatic lesions




Genotype
MGI:5806471
cx4
Allelic
Composition		 Tg(Ela-KRAS*G12D)9Eps/0
Tgfbr1tm1Bopa/Tgfbr1+
Tg(Mt1-TGFBR2*)AM3Epb/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
Tg(Mt1-TGFBR2*)AM3Epb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased gland tumor incidence ( J:231759 )
• mice are protected against pancreatic lesion formation

neoplasm
decreased gland tumor incidence ( J:231759 )
• mice are protected against pancreatic lesion formation




Genotype
MGI:3831111
cx5
Allelic
Composition		 ApcMin/Apc+
Tgfbr1tm1Bopa/Tgfbr1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tgfbr1tm1Bopa mutation (0 available); any Tgfbr1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:143706 )
• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
increased intestinal adenocarcinoma incidence ( J:143706 )
• 3 mice develop large, polyploidy and ulcerated colonic tumors

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:143706 )
• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
increased intestinal adenocarcinoma incidence ( J:143706 )
• 3 mice develop large, polyploidy and ulcerated colonic tumors

cellular
increased cell proliferation ( J:143706 )
• mouse embryonic fibroblasts treated with TGFbeta exhibit a reduced decrease in proliferation compared to similarly treated wild-type mice
• proliferation of intestinal crypt epithelium is increased compared to in wild-type mice

hematopoietic system
hematopoietic system phenotype ( J:143706 )
N
• despite disruptions in cell proliferation, hematopoiesis is normal




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory