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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		En2tm7.1Alj
targeted mutation 7.1, Alexandra L Joyner
MGI:3831095
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster MGI:4421427
cx2
 		En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj 		involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster MGI:4421431


Genotype
MGI:4421427
cn1
Allelic
Composition		 En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Alj mutation (2 available); any En1 mutation (34 available)
En1tm8.1Alj mutation (1 available); any En1 mutation (34 available)
En2tm1Alj mutation (1 available); any En2 mutation (104 available)
En2tm7.1Alj mutation (0 available); any En2 mutation (104 available)
Gt(ROSA)26Sortm1(cre/ERT2)Alj mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum hemisphere lobule morphology ( J:156169 )
• when given tamoxifen at E13.5 or E14. the hemisphere phenotype is more severe than in double mutants that do not express Cre
abnormal cerebellum vermis lobule morphology ( J:156169 )
• when given tamoxifen at E13.5 or E14. the vermis phenotype is more severe than in double mutants that do not express Cre




Genotype
MGI:4421431
cx2
Allelic
Composition		 En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Alj mutation (2 available); any En1 mutation (34 available)
En1tm8.1Alj mutation (1 available); any En1 mutation (34 available)
En2tm1Alj mutation (1 available); any En2 mutation (104 available)
En2tm7.1Alj mutation (0 available); any En2 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum hemisphere lobule morphology ( J:156169 )
• in the hemispheres, CrusII and Paramedian are only partially separated.
abnormal cerebellum vermis lobule morphology ( J:156169 )
• in adults, only one or two major anterior lobules are present, and lobule VIII is very small and fused with dorsal lobule IX.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory