Phenotypes associated with this allele

• Allele Symbol: Ncor1^tm1Laz
• Allele Name: targeted mutation 1, Mitchell A Lazar
• Allele ID: MGI:3831119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncor1^tm1Laz/Ncor1^tm1Laz	C57BL/6-Ncor1^tm1Laz	MGI:3831131

Genotype
MGI:3831131

hm1

• Allelic Composition: Ncor1^tm1Laz/Ncor1^tm1Laz
• Genetic Background: C57BL/6-Ncor1^tm1Laz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced long-term object recognition memory ( J:168224 )

• display enhanced long term memory for object location after subthreshold training

increased food intake ( J:142342 )

• food intake is increased during both day and night periods by about 30-50%

abnormal response to novel object ( J:168224 )

• display enhanced memory in a novel object recognition assay after subthreshold training

shortened circadian behavior period ( J:142342 )

• mice have a free running period of 23.2 hours when in constant darkness compared to 23.6 hours for controls

growth/size/body

decreased body weight ( J:142342 )

• mice are born the same weight as controls but begin to weigh significantly less at 4-6 weeks of age and maintain this weight difference through out their lifespan

decreased susceptibility to diet-induced obesity ( J:142342 )

• mice are resistant to developing obesity when on a high fat diet

adipose tissue

abnormal adipose tissue morphology ( J:142342 )

• adipogenesis from embryonic fibroblasts is modestly increased

decreased white fat cell size ( J:142342 )

• there is a trend of decreased size for adipocytes

decreased gonadal fat pad weight ( J:142342 )

• size and weight of perigonadal fat pad is decreased compared to age-matched controls

decreased percent body fat/body weight ( J:142342 )

• percent body fat is reduced compared to age-matched controls

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:142342 )

• mice are resistant to developing obesity when on a high fat diet

increased circulating ketone body level ( J:142342 )

• there are significantly higher levels of circulating ketones during some parts of the day but not others

increased circulating free fatty acids level ( J:142342 )

• there are significantly higher levels of circulating free fatty acid during some parts of the day but not others

increased oxygen consumption ( J:142342 )

• oxygen consumption is significantly increased at night

abnormal glucose homeostasis ( J:142342 )

• mice have increased hepatic glucose production when fed normal chow but with reduced hepatic glucose production in the setting of the hyperinsulinemic clamp

increased insulin sensitivity ( J:142342 )

• hyperinsulinemic-euglycemic clamp studies reveal increased insulin sensitivity of mice on a normal chow diet

• increased insulin sensitivity is still observed when controls are weight-matched

• mice are also protected against developing insulin resistance with reduced hepatic glucose production in the setting of the hyperinsulinemic clamp

increased basal metabolism ( J:142342 )

• mice have increased oxygen consumption and heat production during their active dark period