All Phenotypes Traf3ip2<tm1Sbn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn	either: B6.129-Traf3ip2^tm1Sbn or (involves: 129) or (involves: 129 * BALB/c)	MGI:3831157
hm2	Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn	involves: 129 * C57BL/6	MGI:5462361
cx3	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm1Sbn/Traf3ip2⁺	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5462253
cx4	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5462346

Allelic Composition	Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn
Genetic Background	either: B6.129-Traf3ip2^tm1Sbn or (involves: 129) or (involves: 129 * BALB/c)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage chemotaxis ( J:144320 )

• bronchoalveolar lavage fluid contains much less macrophages compared to controls 4 days after administration of IL-25 or IL-17

impaired eosinophil recruitment ( J:144320 )

• bronchoalveolar lavage fluid contains much less eosinophils compared to controls 4 days after administration of IL-25 or IL-17

impaired neutrophil recruitment ( J:144320 )

• bronchoalveolar lavage fluid contains much less neutrophils compared to controls 4 days after administration of IL-25 or IL-17

abnormal cytokine secretion ( J:144320 )

• GM-CSF secretion by embryonic fibroblasts is lower than controls, especially when cultured with IL-17 or TNF + IL-17

decreased interleukin-6 secretion ( J:144320 )

• there is lower IL-6 secretion by embryonic fibroblasts than controls, especially when cultured with IL-17 or TNF + IL-17

decreased susceptibility to autoimmune disorder ( J:144320 )

• intranasal administration of IL-25 to wild-type mice leads to an inflammatory airway response similar to asthma with increased secretion of Th2 cytokines, mucus hypersecretion, goblet cell hyperplasia, infiltration of inflammatory cells, collagen deposition around bronchioles, and hyperesponsiveness to methacholine

• IL-25 intranasal treatment fails to increase levels of the Th2 cytokines CCL24, IL-5 and IL-13 in the lung as occurs in wild-type controls

• in response to intranasal administration of IL-25, mutant mice have no goblet cell hyperplasia or mucus hypersecretion compared to 40% of treated wild-type mice

• infiltration of inflammatory cells and collagen deposition around bronchioles are readily apparent in IL-25-treated mice, but not in mutant mice

• mutant mice in the asthma model are not hyperresponsive to methacholine treatment as are wild-type mice

cellular

impaired macrophage chemotaxis ( J:144320 )

• bronchoalveolar lavage fluid contains much less macrophages compared to controls 4 days after administration of IL-25 or IL-17

hematopoietic system

impaired macrophage chemotaxis ( J:144320 )

• bronchoalveolar lavage fluid contains much less macrophages compared to controls 4 days after administration of IL-25 or IL-17

impaired eosinophil recruitment ( J:144320 )

• bronchoalveolar lavage fluid contains much less eosinophils compared to controls 4 days after administration of IL-25 or IL-17

impaired neutrophil recruitment ( J:144320 )

• bronchoalveolar lavage fluid contains much less neutrophils compared to controls 4 days after administration of IL-25 or IL-17

Allelic Composition	Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased inflammatory response ( J:191090 )

• mutants challenged with glomerular basement membrane antibodies in a model of accelerated nephrotoxic nephritis exhibit decreased numbers of neutrophils and monocytes and a trend toward lower counts of macrophages, decreased renal pathology and inflammatory cell infiltrations, indicating protection from development of glomerular basement membrane antibody-induced glomerulonephritis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:191090 )

• only 7.7% of mutants are still alive at 12 months of age

premature death ( J:191090 )

• only 7.7% of mutants are still alive at 12 months of age

renal/urinary system

kidney inflammation ( J:191090 )

• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

immune system

abnormal neutrophil morphology ( J:191090 )

• neutrophil extracellular traps are seen in the kidneys

increased neutrophil cell number ( J:191090 )

• increase in numbers of neutrophils and monocytic cells in perfused kidneys

increased myeloid dendritic cell number ( J:191090 )

• increase in CD11b+CD11c+ myeloid dendritic cells in spleens

increased plasmacytoid dendritic cell number ( J:191090 )

• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens

increased plasma cell number ( J:191090 )

increased monocyte cell number ( J:191090 )

• increase in CD11b+CD11c- monocytic cells in spleens

• increase in numbers of monocytic cells in perfused kidneys

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in numbers of double negative T cells in the kidneys

increased memory T cell number ( J:191090 )

• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)

increased single-positive T cell number ( J:191090 )

• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys

increased spleen germinal center number ( J:191090 )

• form spontaneous germinal centers

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

increased susceptibility to systemic lupus erythematosus ( J:191090 )

• develop fatal lupus

increased autoantibody level ( J:191090 )

• presence of anti-nRNP (ribonucleoprotein) antibodies

increased anti-nuclear antigen antibody level ( J:191090 )

increased anti-double stranded DNA antibody level ( J:191090 )

• presence of double-stranded DNA IgG antibodies

kidney inflammation ( J:191090 )

• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system

abnormal neutrophil morphology ( J:191090 )

• neutrophil extracellular traps are seen in the kidneys

increased neutrophil cell number ( J:191090 )

• increase in numbers of neutrophils and monocytic cells in perfused kidneys

increased myeloid dendritic cell number ( J:191090 )

• increase in CD11b+CD11c+ myeloid dendritic cells in spleens

increased plasmacytoid dendritic cell number ( J:191090 )

• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens

increased plasma cell number ( J:191090 )

increased monocyte cell number ( J:191090 )

• increase in CD11b+CD11c- monocytic cells in spleens

• increase in numbers of monocytic cells in perfused kidneys

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in numbers of double negative T cells in the kidneys

increased memory T cell number ( J:191090 )

• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)

increased single-positive T cell number ( J:191090 )

• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys

increased spleen germinal center number ( J:191090 )

• form spontaneous germinal centers

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:191090

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (48 available)
Traf3ip2^tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:191090 )

• 75% of mutants survive to 12 months of age; this is an 89.7% improvement in survival rate when compared to Fcgr2b nulls heterozygous for Traf3ip2

premature death ( J:191090 )

• 75% of mutants survive to 12 months of age, indicating that 25% die before that time

immune system

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in the numbers of double negative T-cells in the lymph nodes

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

decreased susceptibility to systemic lupus erythematosus ( J:191090 )

• mutants exhibit a reversal of spontaneous germinal center formation, the expansion of plasma cell numbers, and the increased numbers of T effector-memory cells that are seen in Fcgr2b nulls heterozygous for Traf3ip2

• mutants exhibit reduced infiltration of inflammatory cells into kidneys and glomerular pathology is greatly reduced compared to Fcgr2b nulls heterozygous for Traf3ip2

• mutants do not exhibit an increase in CD11b+CD11c- monocytic cells, CD11b+CD11c+ myeloid DCs and CD11c+B220+ plasmacytoid DCs in spleens as seen in Fcgr2b nulls heterozygous for Traf3ip2

increased autoantibody level ( J:191090 )

• presence of anti-nRNP (ribonucleoprotein) antibodies

increased anti-nuclear antigen antibody level ( J:191090 )

increased anti-double stranded DNA antibody level ( J:191090 )

• presence of double-stranded DNA IgG antibodies

hematopoietic system

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in the numbers of double negative T-cells in the lymph nodes

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

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