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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lig4tm1Pmc
targeted mutation 1, Peter J McKinnon
MGI:3831168
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831348
cn2
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831351
cn3
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831355
cn4
 		Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S1/Sv * 129S4/SvJaeSor MGI:3831349
cn5
 		Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:3831346
cn6
 		Lig4tm1Pmc/Lig4tm1Pmc
Mre11atm1Jpt/Mre11atm1Jpt
Tg(Nes-cre)1Kln/0 		involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3831179
cn7
 		Lig4tm1Pmc/Lig4tm1Pmc
Nbntm1Jpt/Nbntm1Jpt
Tg(Nes-cre)1Kln/0 		involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3831185
cn8
 		Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:3831178
cn9
 		Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:3831182


Genotype
MGI:3831348
cn1
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 32 weeks unlike Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln mice with wild-type Trp53

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 94% of mice develop medulloblastoma beginning at 16 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 94% of mice develop medulloblastoma beginning at 16 weeks




Genotype
MGI:3831351
cn2
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 16 weeks

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks




Genotype
MGI:3831355
cn3
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 32 weeks

neoplasm
abnormal tumor morphology ( J:144617 )
• tumors exhibit a loss of heterozygosity at the Trp53 gene
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks




Genotype
MGI:3831349
cn4
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system development ( J:144617 )
• mice exhibit neuraxis-wide apoptosis during development unlike in wild-type mice




Genotype
MGI:3831346
cn5
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal double-strand DNA break repair ( J:226703 )
• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment

nervous system
nervous system phenotype ( J:144617 )
N
• compared to germ line deletions of this gene, mice exhibit no increase in apoptosis during neural development

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:226703 )
• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment




Genotype
MGI:3831179
cn6
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Mre11atm1Jpt/Mre11atm1Jpt
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Mre11atm1Jpt mutation (1 available); any Mre11a mutation (49 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:144172 )
• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system
nervous system phenotype ( J:144172 )
N
• unlike in mice with Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microencephaly is rescued




Genotype
MGI:3831185
cn7
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Nbntm1Jpt/Nbntm1Jpt
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Nbntm1Jpt mutation (1 available); any Nbn mutation (59 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:144172 )
• at E13.5 and E15.5, neural tissue apoptosis is increased compared to in wild-type mice

growth/size/body
microcephaly ( J:144172 )




Genotype
MGI:3831178
cn8
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:144172 )
• at E13.5 and E15.5, neural tissue apoptosis is increased compared to in wild-type mice
• however, brain morphology is otherwise normal
decreased brain size ( J:144172 )
• brain size is reduced as much as 40% compared to in littermate controls

homeostasis/metabolism
abnormal DNA repair ( J:144172 )
• DNA damage in the brain accumulates with age unlike in wild-type mice
• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours

behavior/neurological
ataxia ( J:144172 )
• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

cellular
abnormal DNA repair ( J:144172 )
• DNA damage in the brain accumulates with age unlike in wild-type mice
• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours

growth/size/body
microcephaly ( J:144172 )




Genotype
MGI:3831182
cn9
Allelic
Composition		 Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation (0 available); any Atm mutation (170 available)
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:144172 )
• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system
nervous system phenotype ( J:144172 )
N
• unlike in mice with Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microcephaly is rescued




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory