Phenotypes associated with this allele

• Allele Symbol: Gprc6a^tm1Ldq
• Allele Name: targeted mutation 1, L Darryl Quarles
• Allele ID: MGI:3831176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gprc6a^tm1Ldq/Gprc6a^tm1Ldq	involves: 129X1/SvJ * C57BL/6	MGI:3831191

Genotype
MGI:3831191

hm1

• Allelic Composition: Gprc6a^tm1Ldq/Gprc6a^tm1Ldq
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal external male genitalia morphology ( J:144372 )

♂ • feminization of male external genitalia

♂ • reduced genito-anal distance in males

abnormal internal male genitalia morphology ( J:144372 )

♂

decreased seminal vesicle weight ( J:144372 )

♂

small testis ( J:144372 )

♂ • testes histologically normal

decreased testis weight ( J:144372 )

♂

decreased litter size ( J:144372 )

• fertility is normal for both sexes

• litter size is reduced when male and female homozygotes are mated

homeostasis/metabolism

abnormal circulating hormone level ( J:144372 )

decreased circulating testosterone level ( J:144372 )

• reduced in females

• significantly reduced in males

increased circulating estradiol level ( J:144372 )

• normal estradiol levels in females

• elevated estradiol levels in males

decreased circulating insulin level ( J:144372 )

• reduced serum insulin levels

abnormal circulating phosphate level ( J:144372 )

• serum phosphate levels are elevated

abnormal glucose homeostasis ( J:144372 )

increased circulating glucose level ( J:144372 )

• higher fasting serum glucose

abnormal glucose tolerance ( J:144372 )

• higher serum glucose levels in a glucose tolerance test

increased insulin sensitivity ( J:144372 )

• increased sensitivity to insulin in an insulin tolerance test

increased liver triglyceride level ( J:144372 )

• increased liver triglycerides

abnormal urine homeostasis ( J:144372 )

increased urine calcium level ( J:144372 )

• elevated urinary calcium manifests itself after 6 weeks of age

increased urine phosphate level ( J:144372 )

• elevated urinary phosphate manifests itself at 16 weeks

increased urine beta2-microglobulin level ( J:144372 )

• elevated protein excretion (beta2-microglobulin)

renal/urinary system

abnormal urine homeostasis ( J:144372 )

increased urine calcium level ( J:144372 )

• elevated urinary calcium manifests itself after 6 weeks of age

increased urine phosphate level ( J:144372 )

• elevated urinary phosphate manifests itself at 16 weeks

increased urine beta2-microglobulin level ( J:144372 )

• elevated protein excretion (beta2-microglobulin)

liver/biliary system

increased liver triglyceride level ( J:144372 )

• increased liver triglycerides

hepatic steatosis ( J:144372 )

• histologically

growth/size/body

decreased lean body mass ( J:144372 )

• muscle histology remains normal however

adipose tissue

increased white adipose tissue amount ( J:144372 )

• increased white body fat

skeleton

decreased bone mineral density ( J:144372 )

• no age related increase in bone mineral density

abnormal bone mineralization ( J:144372 )

• diminished mineralization surrounding osteocyte lacunae

• diminished mineralization on periosteal and endosteal surfaces

endocrine/exocrine glands

abnormal mammary gland development ( J:144372 )

♂ • greater ductal outgrowth in the mammary fat pad of males

decreased seminal vesicle weight ( J:144372 )

♂

small testis ( J:144372 )

♂ • testes histologically normal

decreased testis weight ( J:144372 )

♂

integument

abnormal mammary gland development ( J:144372 )

♂ • greater ductal outgrowth in the mammary fat pad of males