Analysis Tools
nervous system
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• CA1 pyramidal neuron dendrites exhibit an 85% drop in linear spine density compared to in wild-type mice
• CA1 pyramidal neuron dendrite spines are smaller than in wild-type mice
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• postsynaptic densities are decreased in both length and thickness compared to in wild-type mice
• the number of synapses is reduced by one-third compared to in wild-type mice
• later stages of synaptogenesis are deficient compared to in wild-type mice
• however, expression of an exogenous Kalrn isoform 7 restores synapse number
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• CA1 pyramidal neuron dendrites exhibit an 85% drop in linear spine density compared to in wild-type mice
• CA1 pyramidal neuron dendrite spines are smaller than in wild-type mice
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• the number of action potentials fired during weak depolarizing current steps is slightly increased while latency to fire the first action potential after step initiation is decreased compared to in wild-type neurons
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• under hyperpolarizing and depolarizing currents, neurons exhibit higher input resistance and lower membrane capacitance compared to wild-type neurons
• however, neurons exhibit normal time constants, resting potential, and action potential threshold under hyperpolarizing and depolarizing currents
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• the frequency of spontaneous excitatory postsynaptic currents is decreased compared to in wild-type mice
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behavior/neurological
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• despite decreased anxiety and contextual conditioning, mice exhibit normal activity levels, learning and object recognition
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• following conditioning, mice exhibit decreased latency to cross to the footshock-paired side compared to wild-type mice without any decrease in pain sensitivity
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• mice spend more time in the open arms of an elevated zero maze, fewer stretch attend postures as they extend from the closed into open area, and greater number of open arm entries compared to wild-type mice without increased activity levels
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