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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr83tm1.1Fpow
targeted mutation 1.1, Fiona Powrie
MGI:3831302
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr83tm1.1Fpow/Gpr83tm1.1Fpow C.129-Gpr83tm1.1Fpow MGI:3831308


Genotype
MGI:3831308
hm1
Allelic
Composition		 Gpr83tm1.1Fpow/Gpr83tm1.1Fpow
Genetic
Background		 C.129-Gpr83tm1.1Fpow
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr83tm1.1Fpow mutation (0 available); any Gpr83 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:144445 )
N
• T regulatory cell development is normal, and mice do not develop colitis
decreased CD4-positive, alpha-beta T cell number ( J:144445 )
• the frequency of CD4+ T cells is decreased compared to in wild-type mice whereas the total numbers are normal

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:144445 )
• the frequency of CD4+ T cells is decreased compared to in wild-type mice whereas the total numbers are normal

growth/size/body
spleen hyperplasia ( J:144445 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory