Phenotypes associated with this allele

• Allele Symbol: Tlr6^m4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:3831306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr6^m4Btlr/Tlr6^m4Btlr	C57BL/6J-Tlr6^m4Btlr	MGI:3831321

Genotype
MGI:3831321

hm1

• Allelic Composition: Tlr6^m4Btlr/Tlr6^m4Btlr
• Genetic Background: C57BL/6J-Tlr6^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:144168 )

• peritoneal macrophages from the index mouse, on three separate occasions, exhibited reduced production of tumor necrosis factor (TNF) alpha in response to the TLR2/6 ligand MALP-2 (macrophage activating lipopeptide 2)

• mutant macrophages exhibited a normal TNF response to signaling via other toll-like receptor (TLR) ligands: the TLR2/1 ligand Pam3CSK4 (triacyl lipopeptide); the TLR4 ligand lipopolysaccharide (LPS); the TLR9 ligand CpG-DNA (single-stranded DNA); the TLR7 ligand resiquimod/R-848 (single-stranded RNA mimetic); and the TLR3 ligand poly I:C (double-stranded RNA)

• although mutant macrophages showed a normal TNF alpha response to the TLR2/6 ligand peptidoglycan (PGN), this is likely due to contamination by a TLR1/2 ligand, as TLR6 deficient mice respond normally to this ligand, whereas TLR2 mutant mice do not

decreased tumor necrosis factor secretion ( J:144168 )

• peritoneal macrophages from the index mouse, on three separate occasions, exhibited reduced production of tumor necrosis factor (TNF) alpha in response to the TLR2/6 ligand MALP-2 (macrophage activating lipopeptide 2)

• mutant macrophages exhibited a normal TNF response to signaling via other toll-like receptor (TLR) ligands: the TLR2/1 ligand Pam3CSK4 (triacyl lipopeptide); the TLR4 ligand lipopolysaccharide (LPS); the TLR9 ligand CpG-DNA (single-stranded DNA); the TLR7 ligand resiquimod/R-848 (single-stranded RNA mimetic); and the TLR3 ligand poly I:C (double-stranded RNA)

• although mutant macrophages showed a normal TNF alpha response to the TLR2/6 ligand peptidoglycan (PGN), this is likely due to contamination by a TLR1/2 ligand, as TLR6 deficient mice respond normally to this ligand, whereas TLR2 mutant mice do not

reproductive system

male infertility ( J:144168 )

♂ • the index male mouse failed to breed by 6 months of age; this may have been due to an independent mutation

hematopoietic system

abnormal macrophage physiology ( J:144168 )

• peritoneal macrophages from the index mouse, on three separate occasions, exhibited reduced production of tumor necrosis factor (TNF) alpha in response to the TLR2/6 ligand MALP-2 (macrophage activating lipopeptide 2)

• mutant macrophages exhibited a normal TNF response to signaling via other toll-like receptor (TLR) ligands: the TLR2/1 ligand Pam3CSK4 (triacyl lipopeptide); the TLR4 ligand lipopolysaccharide (LPS); the TLR9 ligand CpG-DNA (single-stranded DNA); the TLR7 ligand resiquimod/R-848 (single-stranded RNA mimetic); and the TLR3 ligand poly I:C (double-stranded RNA)

• although mutant macrophages showed a normal TNF alpha response to the TLR2/6 ligand peptidoglycan (PGN), this is likely due to contamination by a TLR1/2 ligand, as TLR6 deficient mice respond normally to this ligand, whereas TLR2 mutant mice do not