About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc2tm2Pmc
targeted mutation 2, Peter J McKinnon
MGI:3831320
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831338
cn2
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831351
cn3
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831355
cn4
 		Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:3831335


Genotype
MGI:3831338
cn1
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 28 weeks unlike Xrcc2tm2Pmc/Xrcc2tm2Pmc Tg(Nes-cre)1Kln mice with wild-type Trp53

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 16 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 16 weeks




Genotype
MGI:3831351
cn2
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 16 weeks

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks




Genotype
MGI:3831355
cn3
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 32 weeks

neoplasm
abnormal tumor morphology ( J:144617 )
• tumors exhibit a loss of heterozygosity at the Trp53 gene
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks




Genotype
MGI:3831335
cn4
Allelic
Composition		 Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:144617 )
N
• compared to germ line deletions of this gene, mice exhibit no increase in apoptosis during neural development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory