Analysis Tools
mortality/aging
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• mice are born at the expected Mendelian ratio but die before three weeks of age
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growth/size/body
weight loss
(
J:144416
)
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• starting at 7 days of age, mice fail to gain as much weight as controls
• mice start losing weight at 12 days of age, which continues until their death
|
adipose tissue
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• there is a severe reduction in the amount of subcutaneous fat found at 16 days of age
|
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• the perigonadal fat pad is severely reduced in size at 16 days of age
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homeostasis/metabolism
hypoglycemia
(
J:144416
)
|
• glucose levels are one-third of that in controls at 16 days of age
|
|
• insulin levels are about one-third of that in controls at 16 days of age
|
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• levels of beta-hydroxybutyrate are 2.5 fold higher than that found in controls at 16 days of age
|
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• circulating cholesterol levels are 60% of that found in controls at 16 days of age
|
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• circulating triglyceride levels are only 26% of that found in controls at 16 days of age
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liver/biliary system
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• relative liver weight is only 80% that of controls at 16 days of age
|
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• the liver contains increased numbers of lipid particles that are also enlarged
• free fatty acid levels in the liver are increased two-fold, triglyceride levels 2.8 fold, and cholesterol levels 3.4 fold
|
pale liver
(
J:144416
)
|
• the liver appears pale at 16 days of age
|
immune system
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• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
|
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• thymus cellularity is one-fifth that of wild-type controls after 15 days of age
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• leukocyte numbers are decreased by more than half at 16 days of age compared to controls
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• neutrophil numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
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• lymphocyte numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
|
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• involution of the spleen occurs in the first few weeks of life
• spleen weight per total body weight is normal at 12 days of age, is only 50% of wild-type controls at 14 days of age, and is 36% of wild-type at 16 days of age
|
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• spleen cellularity is one-tenth that of wild-type controls after 15 days of age
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hematopoietic system
|
• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
|
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• thymus cellularity is one-fifth that of wild-type controls after 15 days of age
|
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• leukocyte numbers are decreased by more than half at 16 days of age compared to controls
|
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• neutrophil numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
|
|
• lymphocyte numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
|
|
• involution of the spleen occurs in the first few weeks of life
• spleen weight per total body weight is normal at 12 days of age, is only 50% of wild-type controls at 14 days of age, and is 36% of wild-type at 16 days of age
|
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• spleen cellularity is one-tenth that of wild-type controls after 15 days of age
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integument
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• there is a severe reduction in the amount of subcutaneous fat found at 16 days of age
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endocrine/exocrine glands
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• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
|
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• thymus cellularity is one-fifth that of wild-type controls after 15 days of age
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