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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sac3d1tm1Hnaka
targeted mutation 1, Hideaki Nakajima
MGI:3831538
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sac3d1tm1Hnaka/Sac3d1tm1Hnaka involves: 129P2/OlaHsd MGI:3831539
ht2
 		Sac3d1tm1Hnaka/Sac3d1+ involves: 129P2/OlaHsd MGI:3831540


Genotype
MGI:3831539
hm1
Allelic
Composition		 Sac3d1tm1Hnaka/Sac3d1tm1Hnaka
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sac3d1tm1Hnaka mutation (0 available); any Sac3d1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:144601 )
• CD4+ T cells show a greater proliferative response to TCR stimulation ranging from 1.5-fold to 11-fold depending on the amount of stimulation
• greatest differences in proliferative response were noted at low doses of anti-CD3 stimulation
thymus hyperplasia ( J:144601 )
• thymus cellularity is increased 1.9-fold compared to controls
spleen hyperplasia ( J:144601 )
• spleen cellularity is increased 1.4-fold compared to controls
abnormal mast cell physiology ( J:144601 )
• mast cells proliferate faster in response to low and high doses of IL-3
abnormal B cell physiology ( J:144601 )
• B cells have a 3-fold greater production of IgM in response to IL-5+ anti-CD40 in vitro

hematopoietic system
increased T cell proliferation ( J:144601 )
• CD4+ T cells show a greater proliferative response to TCR stimulation ranging from 1.5-fold to 11-fold depending on the amount of stimulation
• greatest differences in proliferative response were noted at low doses of anti-CD3 stimulation
thymus hyperplasia ( J:144601 )
• thymus cellularity is increased 1.9-fold compared to controls
spleen hyperplasia ( J:144601 )
• spleen cellularity is increased 1.4-fold compared to controls
abnormal bone marrow cell morphology/development ( J:144601 )
• bone marrow cells cultured in vitro with IL-3 and GM-CSF have a 3 to 6 times faster proliferation rate than controls
abnormal common myeloid progenitor cell morphology ( J:144601 )
• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls
increased erythroid progenitor cell number ( J:144601 )
• 3-fold increase in the numbers BFU-E progenitors in the bone marrow compared to controls
• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls
abnormal mast cell physiology ( J:144601 )
• mast cells proliferate faster in response to low and high doses of IL-3
abnormal B cell physiology ( J:144601 )
• B cells have a 3-fold greater production of IgM in response to IL-5+ anti-CD40 in vitro

endocrine/exocrine glands
thymus hyperplasia ( J:144601 )
• thymus cellularity is increased 1.9-fold compared to controls

growth/size/body
spleen hyperplasia ( J:144601 )
• spleen cellularity is increased 1.4-fold compared to controls

cellular
increased T cell proliferation ( J:144601 )
• CD4+ T cells show a greater proliferative response to TCR stimulation ranging from 1.5-fold to 11-fold depending on the amount of stimulation
• greatest differences in proliferative response were noted at low doses of anti-CD3 stimulation




Genotype
MGI:3831540
ht2
Allelic
Composition		 Sac3d1tm1Hnaka/Sac3d1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sac3d1tm1Hnaka mutation (0 available); any Sac3d1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144601 )
• mast cells proliferate faster in response to low and high doses of IL-3

hematopoietic system
abnormal bone marrow cell morphology/development ( J:144601 )
• bone marrow cells cultured in vitro with IL-3 and GM-CSF have a faster proliferation rate than controls
abnormal common myeloid progenitor cell morphology ( J:144601 )
• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls
increased erythroid progenitor cell number ( J:144601 )
• 3-fold increase in the numbers BFU-E progenitors in the bone marrow compared to controls
• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls
abnormal mast cell physiology ( J:144601 )
• mast cells proliferate faster in response to low and high doses of IL-3




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory