Phenotypes associated with this allele

• Allele Symbol: Dyrk3^tm1Dowo
• Allele Name: targeted mutation 1, Don M Wojchowski
• Allele ID: MGI:3831552
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dyrk3^tm1Dowo/Dyrk3^tm1Dowo	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3831651
cx2	Dyrk3^tm1Dowo/Dyrk3^tm1Dowo Epor^tm2Jni/Epor^tm2Jni	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3831652

Genotype
MGI:3831651

hm1

• Allelic Composition: Dyrk3^tm1Dowo/Dyrk3^tm1Dowo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:144586 )

N • mice exhibit normal peripheral blood cell counts and frequencies of myeloid progenitor cells in the bone marrow

abnormal stress erythropoiesis ( J:144586 )

• following treatment with phenylhydrazine or 5-fluorouracil to induce anemia, mice exhibit increased reticulocyte and red blood cell production compared to similarly treated wild-type mice

• in vitro, erythroblast development is accelerated compared to wild-type cells

• when bone marrow is transplanted in to wild-type mice, there is an increase in short-term repopulation compared to when wild-type cells are transplanted

• however, the number of B220+ cells when bone marrow is transplanted into wild-type mice is normal

decreased erythroid progenitor cell number ( J:144586 )

• in the spleen

Genotype
MGI:3831652

cx2

• Allelic Composition: Dyrk3^tm1Dowo/Dyrk3^tm1Dowo; Epor^tm2Jni/Epor^tm2Jni
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

hematopoietic system

abnormal stress erythropoiesis ( J:144586 )

• stress-induced erythropoiesis using 5-fluorouracil is increased compared to in similarly treated Epor^tm2Jni mice