Phenotypes associated with this allele

• Allele Symbol: Slc26a6^tm1Smua
• Allele Name: targeted mutation 1, Shmuel Muallem
• Allele ID: MGI:3831563
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc26a6^tm1Smua/Slc26a6^tm1Smua	involves: 129S6/SvEvTac * C57BL/6J	MGI:3831565

Genotype
MGI:3831565

hm1

• Allelic Composition: Slc26a6^tm1Smua/Slc26a6^tm1Smua
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas physiology ( J:144457 )

• basal Cl^- /HCO3^- exchange is markedly increased in pancreatic duct epithelial cells

• treatment with an inhibitor of CFTR inhibits basal Cl^- /HCO3^- exchange unlike in wild-type mice

• in pancreatic duct epithelial cells basal HCO3^- permeability is increased

abnormal pancreas secretion ( J:144457 )

• enhanced spontaneous fluid secretion by pancreatic duct epithelial cells when incubated in HCO3^- buffered media

• reduced secretin or forskolin stimulated fluid secretion by pancreatic duct epithelial cells

• however, siRNA knockdown Ctfr does inhibit secretion as in wild-type cells