Analysis Tools
immune system
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• thymi of mutant mice contain 10-fold fewer cells than do wild type thymi
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• developing CD4+ T cells in the thymi of mutant mice have reduced expression of the T cell receptor (TCR) component CD3epsilon
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• developing CD8+ T cells in the thymi of mutant mice have reduced expression of the T cell receptor (TCR) component CD3epsilon
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• homozygous mutant mice have reduced numbers of CD4+ T cells in the periphery
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• homozygous mutant mice have reduced numbers of CD8+ T cells in the periphery
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• mutant mice previously immunized with irradiated, adenovirus transformed, syngeneic class I MHC deficient cells exhibit a reduced ability to kill an antigen specific, CD8+ cytotoxic T lymphocyte (CTL) target population (syngeneic splenocytes externally loaded with adenovirus E1B protein)
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hematopoietic system
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• thymi of mutant mice contain 10-fold fewer cells than do wild type thymi
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• developing CD4+ T cells in the thymi of mutant mice have reduced expression of the T cell receptor (TCR) component CD3epsilon
|
|
• developing CD8+ T cells in the thymi of mutant mice have reduced expression of the T cell receptor (TCR) component CD3epsilon
|
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• homozygous mutant mice have reduced numbers of CD4+ T cells in the periphery
|
|
• homozygous mutant mice have reduced numbers of CD8+ T cells in the periphery
|
|
• mutant mice previously immunized with irradiated, adenovirus transformed, syngeneic class I MHC deficient cells exhibit a reduced ability to kill an antigen specific, CD8+ cytotoxic T lymphocyte (CTL) target population (syngeneic splenocytes externally loaded with adenovirus E1B protein)
|
endocrine/exocrine glands
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• thymi of mutant mice contain 10-fold fewer cells than do wild type thymi
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