About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2tm1Jld
targeted mutation 1, Jay L Degen
MGI:3831686
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F2tm1Jld/F2tm1Jld B6.129P2-F2tm1Jld MGI:3831695
ht2
 		F2tm1Jld/F2tm1Sjd involves: 129P2/OlaHsd * C57BL/6J MGI:3831697
cn3
 		F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0 		B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn MGI:3831698
cn4
 		F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:3831696


Genotype
MGI:3831695
hm1
Allelic
Composition		 F2tm1Jld/F2tm1Jld
Genetic
Background		 B6.129P2-F2tm1Jld
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:144572 )
• mice are overtly normal




Genotype
MGI:3831697
ht2
Allelic
Composition		 F2tm1Jld/F2tm1Sjd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
F2tm1Sjd mutation (0 available); any F2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:144572 )
• clotting times are increased compared to in wild-type mice
increased bleeding time ( J:144572 )
• 11 of 16 mice exhibit modest increases in bleeding time compare to wild-type mice
• 5 of 16 mice fail to stop bleeding




Genotype
MGI:3831698
cn3
Allelic
Composition		 F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:144572 )
• following induction with poly(I:C), mice exhibit reduced clearance of S. aureus compared to wild-type mice




Genotype
MGI:3831696
cn4
Allelic
Composition		 F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
F2tm1Sjd mutation (0 available); any F2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144572 )
• following induction with poly(I:C)

cardiovascular system
abnormal heart morphology ( J:144572 )
• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
cardiac fibrosis ( J:144572 )
• aged uninduced mice develop hemosiderin depositions and cardiac fibrosis unlike wild-type mice
hemorrhage ( J:144572 )
• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging with some hemorrhaging in the pleural cavity (in 46% of mice), intracranial cavity (in 46% of mice), or focally within the skeletal muscle (in 18% of mice) unlike in wild-type mice
• however, without induction with poly(I:C) no hemorrhaging is observed
hemothorax ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)
gastrointestinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)
heart hemorrhage ( J:144572 )
• nearly all mice exhibit cardiac hemorrhaging following induction with poly(I:C)
• hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
intracranial hemorrhage ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
cerebellum hemorrhage ( J:144572 )
• following induction with poly(I:C)
muscle hemorrhage ( J:144572 )
• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle
spinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)
skin hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

homeostasis/metabolism
abnormal blood coagulation ( J:144572 )
• clotting time is modestly increased compared to in wild-type mice
• following induction with poly(I:C), clotting time is severely increased compared to in wild-type mice
• however, platelet counts and fibrinogen amounts are normal, and treatment with prothrombin restores normal clotting times
increased bleeding time ( J:144572 )
• following induction with poly(I:C)

nervous system
intracranial hemorrhage ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
cerebellum hemorrhage ( J:144572 )
• following induction with poly(I:C)
spinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

integument
skin hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)
petechiae ( J:144572 )
• occasionally following induction with poly(I:C)

reproductive system
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

respiratory system
hemothorax ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

digestive/alimentary system
gastrointestinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

muscle
muscle hemorrhage ( J:144572 )
• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

endocrine/exocrine glands
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory