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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2tm1Jld
targeted mutation 1, Jay L Degen
MGI:3831686
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F2tm1Jld/F2tm1Jld B6.129P2-F2tm1Jld MGI:3831695
ht2
 		F2tm1Jld/F2tm1Sjd involves: 129P2/OlaHsd * C57BL/6J MGI:3831697
cn3
 		F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0 		B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn MGI:3831698
cn4
 		F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:3831696


Genotype
MGI:3831695
hm1
Allelic
Composition		 F2tm1Jld/F2tm1Jld
Genetic
Background		 B6.129P2-F2tm1Jld
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:144572 )
• mice are overtly normal




Genotype
MGI:3831697
ht2
Allelic
Composition		 F2tm1Jld/F2tm1Sjd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
F2tm1Sjd mutation (0 available); any F2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:144572 )
• clotting times are increased compared to in wild-type mice
increased bleeding time ( J:144572 )
• 11 of 16 mice exhibit modest increases in bleeding time compare to wild-type mice
• 5 of 16 mice fail to stop bleeding




Genotype
MGI:3831698
cn3
Allelic
Composition		 F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:144572 )
• following induction with poly(I:C), mice exhibit reduced clearance of S. aureus compared to wild-type mice




Genotype
MGI:3831696
cn4
Allelic
Composition		 F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (36 available)
F2tm1Sjd mutation (0 available); any F2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144572 )
• following induction with poly(I:C)

cardiovascular system
abnormal heart morphology ( J:144572 )
• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
cardiac fibrosis ( J:144572 )
• aged uninduced mice develop hemosiderin depositions and cardiac fibrosis unlike wild-type mice
hemorrhage ( J:144572 )
• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging with some hemorrhaging in the pleural cavity (in 46% of mice), intracranial cavity (in 46% of mice), or focally within the skeletal muscle (in 18% of mice) unlike in wild-type mice
• however, without induction with poly(I:C) no hemorrhaging is observed
hemothorax ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)
gastrointestinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)
heart hemorrhage ( J:144572 )
• nearly all mice exhibit cardiac hemorrhaging following induction with poly(I:C)
• hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
intracranial hemorrhage ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
cerebellum hemorrhage ( J:144572 )
• following induction with poly(I:C)
muscle hemorrhage ( J:144572 )
• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle
spinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)
skin hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

homeostasis/metabolism
abnormal blood coagulation ( J:144572 )
• clotting time is modestly increased compared to in wild-type mice
• following induction with poly(I:C), clotting time is severely increased compared to in wild-type mice
• however, platelet counts and fibrinogen amounts are normal, and treatment with prothrombin restores normal clotting times
increased bleeding time ( J:144572 )
• following induction with poly(I:C)

nervous system
intracranial hemorrhage ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
cerebellum hemorrhage ( J:144572 )
• following induction with poly(I:C)
spinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

integument
skin hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)
petechiae ( J:144572 )
• occasionally following induction with poly(I:C)

reproductive system
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

respiratory system
hemothorax ( J:144572 )
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

digestive/alimentary system
gastrointestinal hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

muscle
muscle hemorrhage ( J:144572 )
• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

endocrine/exocrine glands
testicular hemorrhage ( J:144572 )
• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory