Phenotypes associated with this allele

• Allele Symbol: Cdc25a^tm1Dvb
• Allele Name: targeted mutation 1, Dmitry V Bulavin
• Allele ID: MGI:3831687
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc25a^tm1Dvb/Cdc25a^tm1Dvb	involves: 129	MGI:3831692

Genotype
MGI:3831692

hm1

• Allelic Composition: Cdc25a^tm1Dvb/Cdc25a^tm1Dvb
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal centrosome morphology ( J:144548 )

• after irradiation, dermal fibroblasts have an increased incidence of 3 or more centrosomes

aneuploidy ( J:144548 )

• a fraction of aneuploid cells with nearly 4N DNA content are observed in cells arrested at the mitotic stage

abnormal mitosis ( J:144548 )

• there is a significant increase in the number of dermal fibroblasts that have three or more centrosomes when entering mitosis after irradiation

increased cellular sensitivity to gamma-irradiation ( J:144548 )

• after irradiation, dermal fibroblasts have an increased incidence of 3 or more centrosomes, aneuploidy, and other non-specified chromosomal abnormalities

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:144548 )

• after receiving 4 Gy of radiation, 80% of mutant mice develop tumors at 600 days of age compared to 30% of wild-type controls

• 18 months after receiving 4 Gy of radiation, there is a 3-fold increase in the number of mice that have died from cancerous tumors compared to irradiated wild-type controls

• the median lifespan of the irradiated mice is 485 days compared to over 600 for the controls