Phenotypes associated with this allele

• Allele Symbol: Cnr1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3831701
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnr1^tm1Dgen/Cnr1^tm1Dgen	involves: 129S1/Sv * 129X1/SvJ	MGI:3831870
hm2	Cnr1^tm1Dgen/Cnr1^tm1Dgen	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3831869

Genotype
MGI:3831870

hm1

• Allelic Composition: Cnr1^tm1Dgen/Cnr1^tm1Dgen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:144774 )

• mice fail to exhibit catalepsy following administration of WIN55,212-2 unlike wild-type mice

• however, mice respond normally following spinal nuclear ligation and treatment with AM1241

Genotype
MGI:3831869

hm2

• Allelic Composition: Cnr1^tm1Dgen/Cnr1^tm1Dgen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

nervous system

nervous system phenotype ( J:143885 )

N • quinpirole-induced depression of inhibitory postsynaptic currents is normal

N • induced long-term depression of inhibitory postsynaptic currents (I-LTD) induced by 10 Hz stimulation with 10 um cocaine is normal

reduced long-term depression ( J:144773 )

• stimulation by 10 Hz, for 5 minutes plus 3 um cocaine failed to induced long-term depression of inhibitory postsynaptic currents (I-LTD) in dopaminergic neurons from the ventral tegmental area unlike in wild-type mice